Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism
Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism
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DOI：
10.1507/endocrj.ej15-0362
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发表时间：
2016-03-20
影响因子：
2
通讯作者：
Takayanagi, Ryoichi
中科院分区：
文献类型：
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作者：
Matsuda, Yayoi;Kawate, Hisaya;Takayanagi, Ryoichi
原发性醛固酮增多症（PA）比原发性高血压与更高的心血管事件发生率相关。尽管有报道称肾上腺切除术可降低PA患者颈动脉内膜-中膜厚度（IMT），但选择性醛固酮阻滞剂eplerenone对这些患者血管损伤的影响尚不清楚。为了评估依普利酮对PA患者血管状态的影响，我们对22例患者进行了颈动脉IMT（使用计算机软件计算平均IMT，以获得准确和可重复的评估）的连续测量，其中包括8例单侧肾上腺切除术患者和14例依普利酮治疗12个月的患者。接受肾上腺切除术的患者醛固酮浓度显著降低(从345 +/- 176 pg/mL降至67 +/- 34 pg/mL
Primary aldosteronism (PA) is associated with a higher rate of cardiovascular events than essential hypertension. Although adrenalectomy has been reported to reduce carotid intima-media thickness (IMT) in patients with PA, the effects of the selective aldosterone blocker, eplerenone, on vascular damage in these patients remains unclear. To evaluate the effects of eplerenone on vascular status in PA patients, we sequentially measured carotid IMT (using computer software to calculate an average IMT for accurate and reproducible evaluation) in 22 patients including 8 patients treated by unilateral adrenalectomy and 14 patients treated with eplerenone for 12 months. Patients who underwent adrenalectomy showed significant reductions in aldosterone concentration (from 345 +/- 176 pg/mL to 67 +/- 34 pg/mL; P