simuG: a general-purpose genome simulator
simuG: a general-purpose genome simulator
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DOI：
10.1093/bioinformatics/btz424
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发表时间：
2019-11-01
期刊：
影响因子：
5.8
通讯作者：
Liti, Gianni
中科院分区：
文献类型：
--
作者：
Yue, Jia-Xing;Liti, Gianni
具有预定义和随机基因组变体的模拟基因组对于基准基因组和生物信息学分析非常有用。在这里，我们介绍simuG，一个轻量级的工具，用于模拟任何生物（包括人类）的全谱基因组变异（单核苷酸多态性，插入/缺失，拷贝数变异，倒置和易位）。simuG的简单性和多功能性使其成为一种独特的通用基因组模拟器，适用于广泛的基于模拟的应用。
Simulated genomes with pre-defined and random genomic variants can be very useful for benchmarking genomic and bioinformatics analyses. Here we introduce simuG, a lightweight tool for simulating the full-spectrum of genomic variants (single nucleotide polymorphisms, Insertions/Deletions, copy number variants, inversions and translocations) for any organisms (including human). The simplicity and versatility of simuG make it a unique general-purpose genome simulator for a wide-range of simulation-based applications.