Vitamin D and Cancer Incidence in the Harvard Cohorts
Vitamin D and Cancer Incidence in the Harvard Cohorts
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DOI：
10.1016/j.annepidem.2007.12.002
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发表时间：
2009-02-01
影响因子：
5.6
通讯作者：
Giovannucci, Edward
中科院分区：
文献类型：
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作者：
Giovannucci, Edward
自1980年提出维生素D可降低某些癌症风险的假设以来，哈佛队列研究已对这一假设进行了研究，包括护士健康研究（NHS）、健康专业人员随访研究（HPFS）和医生健康研究（PHS）。采用了三种方法，研究循环25（OH）维生素D（25（OH）D）水平、膳食和补充摄入量以及预测25（OH）D。这些队列强烈支持与结直肠癌的负相关性，因为在NHS和HPFS队列中，癌症和腺瘤以及血浆、饮食和预测的25（OH）D分析中都观察到了这种相关性。在NHS中，观察到乳腺癌风险降低约30%，比较25（OH）D水平的最高和最低五分位数。维生素D摄入量也与男性和女性胰腺癌风险降低有关，但血浆或预测的25（OH）D水平或饮食摄入量的研究通常不支持维生素D状态在中年或老年男性前列腺癌风险中的主要作用。HPFS的结果还表明，非洲裔美国人的维生素D状况普遍较差，导致各种恶性肿瘤的发病率和死亡率较高。
Since the hypothesis that vitamin D reduces the risk of some cancers was initiated in 1980, this hypothesis has been studied in the Harvard cohort studies, including the Nurses' Health Study (NHS), the Health Professionals Follow-Up Study (HPFS), and the Physicians' Health Study (PHS). Three approaches have been used, the study of circulating 25(OH)vitamin D (25(OH)D) level, of dietary and supplementary intake, and of predicted 25(OH)D. These cohorts strongly support an inverse association with colorectal cancer, because this association has been viewed in both the NHS and HPFS cohorts, for cancers and adenomas, and for plasma, diet, and predicted 25(OH)D analyses. In the NHS, about a 30% reduction in risk was observed for breast cancer comparing the highest with lowest quintiles of 25(OH)D levels. Vitamin D intake also was associated with a lower risk of pancreatic cancer in both men and women, but studies of plasma or predicted 25(OH)D level or dietary intake have generally not been supportive of a major role of vitamin D status in middle-age or elderly men on prostate cancer risk. Results from the HPFS also suggest that the poor vitamin D status generally in African-Americans contributes to their higher incidence and mortality from various malignancies.