Prognostic potential of mid-treatment nodal response in oropharyngeal squamous cell carcinoma.
Prognostic potential of mid-treatment nodal response in oropharyngeal squamous cell carcinoma.
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口咽鳞状细胞癌中治疗淋巴结反应的预后潜力。
DOI:
10.1002/hed.26467
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发表时间:
2020-09-21
期刊:
影响因子:
--
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中科院分区:
文献类型:
--
作者:
We examine the prognostic implications of mid-course nodal response in oropharyngeal cancer (OPX) to radiation therapy. In 44 patients with node-positive OPX undergoing concurrent chemoradiation, nodal volumes were measured on cone beam CTs from days 1, 10, 20, and 35. Nodal decrease (ND) was based on percent shrinkage from day 1. At a median follow-up of 17 months, the 2-year disease-free survival (DFS), locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) were 87%, 92%, 89%, and 92%, respectively. Patients with ND ≥43% at D20 had improved LRC (100% vs 78.4%, P = .03) compared to D20 ND <43%. On multivariate analysis, D20 ≥43% was independently prognostic for LRC (HR 1.17, P = .05). Patients with low-risk oropharynx cancer with ND of ≥43% by treatment day 20 had significantly improved LRC. The prognostic benefit of ND may assist in identifying candidates for treatment de-escalation.
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影响因子:
9.3
作者:
Hoeben, Bianca A. W.;Troost, Esther G. C.;Kaanders, Johannes H. A. M.
通讯作者:
Kaanders, Johannes H. A. M.
DOI:
10.1016/s1470-2045(17)30252-8
发表时间:
2017-05
期刊:
The Lancet. Oncology
影响因子:
--
作者:
Caudell JJ;Torres-Roca JF;Gillies RJ;Enderling H;Kim S;Rishi A;Moros EG;Harrison LB
通讯作者:
Harrison LB
DOI:
10.1016/j.ijrobp.2015.02.017
发表时间:
2015-07-01
影响因子:
7
作者:
Jabbour, Salma K.;Kim, Sinae;Zou, Wei
通讯作者:
Zou, Wei
影响因子:
158.5
作者:
Bonner, JA;Harari, PM;Ang, KK
通讯作者:
Ang, KK
影响因子:
11.2
作者:
Torres-Roca, JF;Eschrich, S;Yeatman, T
通讯作者:
Yeatman, T