Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites
Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites
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DOI：
10.1128/iai.70.10.5751-5758.2002
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发表时间：
2002-10-01
影响因子：
3.1
通讯作者：
Cowman, AF
中科院分区：
文献类型：
--
作者：
Healer, J;Crawford, S;Cowman, AF
恶性疟原虫顶膜抗原1（PfAMA 1）含有在成熟蛋白易位到裂殖子表面之前被去除的N-末端前肽。我们将未加工的PfAMA 1定位于红细胞内线粒体的微线细胞器。结果表明，PfAMA 1的加工形式从微线区室独立于另一种微线蛋白EBA 175易位，EBA 175也参与了人红细胞的侵袭。
Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.