UNICOLOR AND BICOLOR INSITU HYBRIDIZATION IN THE DIAGNOSIS OF PERIPHERAL NEUROEPITHELIOMA AND RELATED TUMORS

UNICOLOR AND BICOLOR INSITU HYBRIDIZATION IN THE DIAGNOSIS OF PERIPHERAL NEUROEPITHELIOMA AND RELATED TUMORS
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DOI:
10.1002/gcc.2870050105
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发表时间:
1992-07-01
影响因子:
3.7
通讯作者:
AURIAS, A
AURIAS, A
中科院分区:
医学2区
文献类型:
--
作者:
DESMAZE, C;ZUCMAN, J;AURIAS, A

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The chromosome 22 breakpoint of the t(11;22) translocation of peripheral neuroepithelioma has been located, by fluorescence in situ hybridization, in the proximity of the interface between 22q 12.1 and 22q 12.2. Use of single cosmids or pools of cosmids of the flanking regions enables the monitoring of the translocation in interphase and in metaphase chromosomes. This method can now be routinely applied for the diagnosis of this translocation in mixed round cell tumors.