N-alkyl cysteine-assisted thioesterification of peptides
N-alkyl cysteine-assisted thioesterification of peptides
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DOI：
10.1016/j.tetlet.2006.11.034
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发表时间：
2007-01-01
影响因子：
1.8
通讯作者：
Nakahara, Yoshiaki
中科院分区：
文献类型：
--
作者：
Hojo, Hironobu;Onuma, Yuko;Nakahara, Yoshiaki
提出了一种新的固相后肽合成法（SPPS）制备肽硫酯的方法。制备了一系列N-烷基半胱氨酸衍生物，并将其用作通过Fmoc SPPS制备的肽的C-末端残基。在3-巯基丙酸（MPA）水溶液中，通过TFA从树脂释放的合成肽容易地转化为肽硫酯，而没有显著的副反应。(c)2006爱思唯尔有限公司保留所有权利。
A new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc SPPS. The synthetic peptides released from resin by TFA were readily converted to the peptide thioester in aqueous 3-mercaptopropionic acid (MPA) without significant side reactions. (c) 2006 Elsevier Ltd. All rights reserved.