ENHANCED CONVERSION OF ANDROSTENEDIONE TO ESTROGENS IN OBESE MALES
ENHANCED CONVERSION OF ANDROSTENEDIONE TO ESTROGENS IN OBESE MALES
复制标题
DOI：
10.1210/jcem-51-5-1128
复制
发表时间：
1980-01-01
影响因子：
5.8
通讯作者：
KRUSKEMPER, HL
中科院分区：
文献类型：
--
作者：
KLEY, HK;DESELAERS, T;KRUSKEMPER, HL
测定了正常和肥胖青年男性[理想体重(IBW)的90-120%和160%；IBW=100%]的血浆睾酮[T]、雄烯二酮[A]、雌酮[E]和雌二醇[E]的浓度。采用恒定输液法测定雄烯二酮的代谢清除量[MCR]、产生率以及雄烯二酮与睾酮、雌酮和雌二醇的转化率。肥胖组IBW与血浆A(r=0.81)、T(r=0.87)呈负相关(P<；0.001)，E(r=0.92)、E_2(r=0.95)与IBW(P<；0.001)呈正相关。当正常受试者和肥胖者分组比较时，血浆A降低1.24±-。0.13-0.93.+-0.15 ng/ml(平均值+-SD)，血浆T下降5.89.+-。0.82-3.29+-0.92 ng/ml(P<；0.001)；E增加28.2±-。3.4-60.0.+-9.4pg/ml，E_2升高21.7pg/ml。3.5-43.9+-肥胖组T/A、E_2/E比值无显著差异，但IBW变化与E/A、E_2/T比值的变化呈正相关(P<；0.001)，提示脂肪组织可使雄激素芳香化，而17-氧类固醇的减少似乎并不重要。随着出生体重的增加，A的MCR增加(从2156-2636 L/天，P<；0.05)，而血浆水平下降，A的表观产生率不受肥胖程度的影响。肥胖组(P<；0.001)A向E的转换(r=0.89)和A向E的转换(r=0.82)均增强。显然，由于脂肪组织质量增加，雄烯二酮芳构化增强，这可能是肥胖男性血浆雌激素水平较高的原因。
In normal and obese young males [90-120% and > 160% of ideal body weight (IBW); IBW = 100%], plasma concentrations of testosterone [T], androstenedione [A], estrone [E] and estradiol [E2] were measured. Metabolic clearance [MCR] and production rates of androstenedione and the conversion ratios of androstenedione to testosterone, estrone and estradiol were determined using the constant infusion technique. In the obese subjects, IBW was inversely correlated (P < 0.001) with plasma concentrations of A (r = 0.81) and T (r = 0.87); the levels of E (r = 0.92) and E2 (r = 0.95) increased with IBW (P < 0.001). When normal and obese subjects were compared as groups, plasma A decreased 1.24 .+-. 0.13-0.93 .+-. 0.15 ng/ml (mean .+-. SD) and plasma T decreased 5.89 .+-. 0.82-3.29 .+-. 0.92 ng/ml (P < 0.001); E increased 28.2 .+-. 3.4-60.0 .+-. 9.4 pg/ml and E2 increased 21.7 .+-. 3.5-43.9 .+-. 5.3 pg/ml. The T to A and the E2 to E ratios were not different in obesity but changes in IBW were positively correlated (P < 0.001) with differences in the E to A (r = 0.93) and E2 to T ratios (r = 0.93), indicating that fat tissue may aromatize androgens, whereas reduction of 17-oxosteroids appears to be of minor importance. As the MCR of A increased with IBW (from 2156-2636 l/day, P < 0.05), while plasma levels decreased, the apparent production rate of A was not influenced by the degree of obesity. The conversion of A to E (r = 0.89) and of A to E2 (r = 0.82) was enhanced in obese subjects (P < 0.001). Apparently, enhanced aromatization of androstenedione due to an increased adipose tissue mass may account for the high plasma estrogen levels observed in obese men.