FUNCTIONAL INTERACTIONS BETWEEN INFEROTEMPORAL AND PREFRONTAL CORTEX IN A COGNITIVE TASK
FUNCTIONAL INTERACTIONS BETWEEN INFEROTEMPORAL AND PREFRONTAL CORTEX IN A COGNITIVE TASK
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DOI：
10.1016/0006-8993(85)90689-4
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发表时间：
1985-01-01
期刊：
影响因子：
2.9
通讯作者：
JERVEY, JP
中科院分区：
文献类型：
--
作者：
FUSTER, JM;BAUER, RH;JERVEY, JP
训练猕猴进行视觉短期记忆任务（延迟匹配样本）。在一些动物中，冷却探针被植入背外侧前额叶皮层，覆盖主沟和邻近区域;微电极植入颞下皮层。其他动物则被植入匡威的植入物：在颞下皮质凸面的一部分上植入冷却探针，在前额皮质上植入微电极。在清醒和正常的猴子中，前额或颞下区的双侧冷却（至20 ° C）。C）在另一区域中诱导自发和任务相关细胞放电的可逆变化。在2个皮层中，远程冷却诱导了对颜色样本的细胞反应的增强和减弱，动物必须保留这些颜色样本以正确执行任务。在延迟期间，即每个样品之后的保留期，电池放电也是如此。远程冷却的净效应是，在两个皮层中，一些细胞的反应和延迟放电的颜色依赖性差异减少。与此同时，任务执行错误增加。细胞，作为远程皮层冷却的结果显示的颜色样品的反应的变化被发现更常见于颗粒上比颗粒下层。显然，颞下区和前额区之间存在相互影响，可能是通过皮质联系介导的。这些影响对于视觉辨别和短期记忆具有重要的功能。
Macaque monkeys were trained to perform a visual short-term memory task (delayed matching to sample). In some of the animals, cooling probes were implanted over dorsolateral prefrontal cortex, covering sulcus principalis and adjacent areas; microelectrode pedestals were implanted over inferotemporal cortex. Other animals were fitted with converse implants: cooling probes over a portion of the inferotemporal cortical convexity and microelectrode pedestals over prefrontal cortex. In the awake and behaving monkeys, bilateral cooling of either the prefrontal or the inferotemporal region (to 20.degree. C) induced, in the other region, reversible changes of spontaneous and task-related cell discharge. In the 2 cortices remote cooling induced augmentations and diminutions of cell reaction to the color samples which the animal had to retain for correct performance of the task. The same was true for cell discharge during the delay, the retention period which followed each sample. A net effect of remote cooling was, in both cortices, a diminution of color-dependent differences in the reactions and delay-discharge of some cells. Concomitantly, errors of task-performance increased. Cells that as a result of remote cortical cooling showed changes of reaction to the color samples were found more commonly in supragranular than infragranular layers. Evidently, there are mutual influences between inferotemporal and prefrontal areas, probably mediated by corticocortical connections. Those influences are functionally important for visual discrimination and short-term memory.