Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection.
Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection.
复制标题
不同病毒传播模式对人类免疫缺陷病毒感染中多重感染细胞动态的影响。
DOI：
10.1098/rsif.2010.0266
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Levy,DavidN
中科院分区：
文献类型：
--
作者：
Wodarz,Dominik;Levy,DavidN
Infection of individual cells with more than one HIV particle is an important feature of HIV replication, which may contribute to HIV pathogenesis via the occurrence of recombination, viral complementation and other outcomes that influence HIV replication and evolutionary dynamics. A previous mathematical model of co-infection has shown that the number of cells infected withiviruses correlates with theith power of the singly infected cell population, and this has partly been observed in experiments. This model, however, assumed that virus spread from cell to cell occurs only via free virus particles, and that viruses and cells mix perfectly. Here, we introduce a cellular automaton model that takes into account different modes of virus spread among cells, including cell to cell transmission via the virological synapse, and spatially constrained virus spread. In these scenarios, it is found that the number of multiply infected cells correlates linearly with the number of singly infected cells, meaning that co-infection plays a greater role at lower virus loads. The model further indicates that current experimental systems that are used to study co-infection dynamics fail to reflect the true dynamics of multiply infected cells under these specific assumptions, and that new experimental techniques need to be designed to distinguish between the different assumptions.
