MR imaging and spectroscopy using hyperpolarized Xe-129 gas: Preliminary human results
MR imaging and spectroscopy using hyperpolarized Xe-129 gas: Preliminary human results
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DOI：
10.1002/mrm.1910370602
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发表时间：
1997-06-01
影响因子：
3.3
通讯作者：
Wagshul, ME
中科院分区：
文献类型：
--
作者：
Mugler, JP;Driehuys, B;Wagshul, ME
利用一种新的氙激光偏振方法，可以产生一升超偏振的Xe-129气体，第一次从人体胸部获得了Xe-129成像结果，第一次从人体胸部和头部获得了Xe-129光谱结果。在偏振水平约为2%的情况下，获得了体素体积为0.9 cm(3)(信噪比，28)的肺气腔的横断面图像，并在胸部光谱中检测到三个溶解相共振，在头部光谱中检测到一个显著的溶解相共振，推测来自脑实质。随着Xe-129极化系统、脉冲序列、RF线圈和呼吸动作的预期改进，这些结果表明Xe-129肺部气相成像的分辨率可能接近当前传统的胸腔质子成像。此外，结果还表明，胸部和大脑的溶解相成像是可行的，其分辨率与气相成像的分辨率相似。
Using a new method of xenon laser-polarization that permits the generation of liter quantities of hyperpolarized Xe-129 gas, the first Xe-129 imaging results from the human chest and the first Xe-129 spectroscopy results from the human chest and head have been obtained. With polarization levels of approximately 2%, cross-sectional images of the lung gas-spaces with a voxel volume of 0.9 cm(3) (signal-to-noise ratio (SNR), 28) were acquired and three dissolved-phase resonances in spectra from the chest were detected, In spectra from the head, one prominent dissolved-phase resonance, presumably from brain parenchyma, was detected. With anticipated improvements in the Xe-129 polarization system, pulse sequences, RF coils, and breathing maneuvers, these results suggest the possibility for Xe-129 gas-phase imaging of the lungs with a resolution approaching that of current conventional thoracic proton imaging. Moreover, the results suggest the feasibility of dissolved-phase imaging of both the chest and brain with a resolution similar to that obtained with the gas-phase images.