Availability of insulin from parenteral nutrient solutions.
Availability of insulin from parenteral nutrient solutions.
复制标题
从肠外营养液中获取胰岛素。
DOI：
--
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
E. A. Jackson
中科院分区：
文献类型：
--
作者：
S. S. Weber;W. A. Wood;E. A. Jackson
研究了以下变量对全肠外营养液中胰岛素丢失的影响：(1)输液时间；(2)胰岛素浓度；(3)氨基酸或多肽来源；(4)电解质和维生素；(5)在线过滤器；(6)玻璃和聚氯乙烯(PVC)输液容器；(7)人血清白蛋白。将I125标记的胰岛素添加到升容器中的各种肠外营养液中。这些溶液的制备和排出是为了模拟实际的临床使用。收集引流液并测量放射性，计算胰岛素在输液容器中的残留百分比。氨基酸和蛋白质水解物在葡萄糖和30个单位的胰岛素中的基本溶液未能提供大约44%到47%的添加的胰岛素。改变胰岛素浓度对胰岛素丢失程度的影响很小，但有统计学意义。使用直插式过滤器和聚氯乙烯袋会造成更大的胰岛素损失。白蛋白或电解质和维生素的添加减少了胰岛素的损失。
The effect of the following variables on insulin loss from total parenteral nutrient solutions was examined: (1) time of infusion sample; (2) insulin concentration; (3) amino acid or polypeptide source; (4) electrolytes and vitamins; (5) inline filters; (6) glass and polyvinyl chloride (PVC) infusion containers; and (7) human albumin. I125-tagged insulin was added to various parenteral nutrient solutions in liter containers. These solutions were prepared and drained to simulate actual clinical use. The drained solutions were collected and measured for radioactivity, and the percent of insulin remaining in the infusion container was calculated. Basic solutions of amino acids and protein hydrolysates in dextrose with 30 units of insulin failed to deliver approximately 44 to 47% of the added insulin. Varying the concentration of insulin had a small but statistically significant effect on the degree of insulin loss. The use of inline filters and PVC bags caused an even greater loss of insulin. The addition of albumin or electrolytes and vitamins decreased the insulin loss.