Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots.
Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots.
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DOI：
10.2174/1874440000802010094
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发表时间：
2008-09-27
期刊：
影响因子：
--
通讯作者：
Tzika, A Aria
中科院分区：
文献类型：
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作者：
Mintzopoulos, Dionyssios;Khanicheh, Azadeh;Tzika, A Aria
我们通过将功能磁共振成像 (fMRI) 与新型 MR 兼容的手诱导机器人设备 (MR_CHIROD) 相结合来监测慢性中风后的大脑活动。我们在 3 T MR 系统上评估了 60 个 fMRI 数据集，这些数据集来自 5 名右手患者，这些患者患有≥6 个月前的左侧卒中和轻度至中度偏瘫。患者用健身球训练瘫痪右手约最大力量的 75%，每天 1 小时，每周 3 天，持续 4 周。当参与者使用 MR_CHIROD 时，使用通用自动校准部分并行采集 (GRAPPA) 并行成像在训练之前、训练期间、训练完成时和非训练期之后获取多级 fMRI 数据。训练增加了激活的感觉运动皮质体素的数量，表明慢性中风患者的功能性皮质可塑性。这种效果在训练完成后持续四个星期，表明康复在诱导慢性中风患者皮质可塑性方面具有潜力。
We monitored brain activation after chronic stroke by combining functional magnetic resonance imaging (fMRI) with a novel MR-compatible, hand-induced, robotic device (MR_CHIROD). We evaluated 60 fMRI datasets on a 3 T MR system from five right-handed patients with left-sided stroke >/=6 months prior and mild to moderate hemiparesis. Patients trained the paretic right hand at approximately 75% of maximum strength with an exercise ball for 1 hour/day, 3 days/week for 4 weeks. Multi-level fMRI data were acquired before, during training, upon completion of training, and after a non-training period using parallel imaging employing GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) while the participant used the MR_CHIROD. Training increased the number of activated sensorimotor cortical voxels, indicating functional cortical plasticity in chronic stroke patients. The effect persisted four weeks after training completion, indicating the potential of rehabilitation in inducing cortical plasticity in chronic stroke patients.