3-DIMENSIONAL ANALYSIS OF AUDITORY-EVOKED POTENTIALS IN RAT NEOCORTEX
3-DIMENSIONAL ANALYSIS OF AUDITORY-EVOKED POTENTIALS IN RAT NEOCORTEX
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DOI：
10.1152/jn.1990.64.5.1527
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发表时间：
1990-11-01
影响因子：
2.5
通讯作者：
DI, S
中科院分区：
文献类型：
--
作者：
BARTH, DS;DI, S
1. 采用8 × 8通道微电极阵列绘制了4只大鼠右侧顶叶新皮层8 × 8 mm2区域双侧呈现的点击刺激所诱发的上皮层场电位。在2只大鼠初级听觉皮层内插入16通道微电极阵列，记录听觉诱发电位（AEP）的层流分布。2. 皮层反应以正-负快波开始，然后是正-负慢波，类似于先前报道的P1， N1, P2， N2复合体。这些波的峰值电位的地形分布是不同的，这表明它们是由分开但重叠的细胞群产生的。3. 层流记录揭示了核上和核下锥体细胞在诱发反应复合体的产生过程中的非同步参与。表面记录的P1主要由小颗粒上细胞产生，N1主要由小颗粒内细胞产生。P2和N2是由两个细胞组在时间上重叠贡献产生的。4. 我们得出结论，AEP复合体的中潜伏期成分是由初级听觉皮层锥体细胞亚群的顺序和平行激活产生的。
1. A 8 X 8-channel microelectrode array was used to map epicortical field potentials evoked by bilaterally presented click stimuli from a 8 X 8-mm2 area in the right parietotemporal neocortex of four rats. In two rats, a 16-channel microelectrode array was also inserted into primary auditory cortex to record the laminar profile of auditory evoked potentials (AEP). 2. The epicortical responses began with a positive-negative fast wave followed by a positive-negative slow wave, similar to the previously reported P1, N1, P2, N2 complex. Topographical distributions of the potentials at the peak of each of these waves were distinct, suggesting that they were produced by separate but overlapping populations of cells. 3. Laminar recording revealed the asynchronous participation of supragranular and infragranular pyramidal cells in the generation of the evoked-response complex. The surface-recorded P1 was primarily produced by supragranular cells and the N1, by infragranular cells. The P2 and N2 were produced by temporally overlapping contributions from both cell groups. 4. We conclude that middle-latency components of the AEP complex are produced by both sequential and parallel activation of subpopulations of pyramidal cells in primary auditory cortex.