Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus
Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus
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DOI：
10.1292/jvms.13-0003
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发表时间：
2013-08-01
影响因子：
1.2
通讯作者：
Maeda, Ken
中科院分区：
文献类型：
--
作者：
Hara, Yuka;Suzuki, Junko;Maeda, Ken
麻疹病毒使用信号淋巴细胞活化分子（SLAM）作为它们进入细胞的受体。在这项研究中，一个完整的基因编码SLAM的家猫被确定。猫SLAM与犬SLAM的同一性为73%，猫SLAM与食肉动物SLAM形成同一簇。此外，表达猫SLAM的猫细胞支持犬瘟热病毒（CDV）以及表达犬瘟热病毒的细胞的生长。这些结果表明，猫SLAM可以作为麻疹病毒的受体，我们建立的猫细胞表达猫SLAM可能是有用的分析麻疹病毒来源于猫科动物。
Morbilliviruses use signaling lymphocyte activation molecule (SLAM) as a receptor for their entry to cells. In this study, a complete gene encoding SLAM of a domestic cat was identified. The identity of feline SLAM with canine one was 73%, and feline SLAM formed the same cluster with those of carnivores. Furthermore, feline cell expressing feline SLAM supported growth of canine distemper virus (CDV) as well as that expressing canine one. These results indicated that feline SLAM can function as a receptor for morbilliviruses, and our established feline cells that express feline SLAM might be useful for analysis of morbilliviruses originated from felids.