Female third party lymphocytes are effective for immunotherapy of patients with unexplained primary recurrent spontaneous abortion: A retrospective analysis of outcomes
Female third party lymphocytes are effective for immunotherapy of patients with unexplained primary recurrent spontaneous abortion: A retrospective analysis of outcomes
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DOI：
10.3109/13625187.2015.1046593
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发表时间：
2015-11-02
影响因子：
1.7
通讯作者：
Lin, Qide
中科院分区：
文献类型：
--
作者：
Xu, Liang;Qiu, Tian;Lin, Qide
目的父亲来源或由男性第三方提供的同种异体淋巴细胞已被用于治疗复发性自然流产。然而，很少有研究研究女性第三方淋巴细胞的使用情况。目的探讨女性第三方淋巴细胞能否用于反复自然流产患者的免疫治疗。方法采用回顾性非随机队列对照研究方法，对1996~2012年间三次或三次以上自然流产患者接受其配偶、男性第三方或女性第三方淋巴细胞免疫治疗以及未接受免疫治疗的病例资料进行回顾分析。所有患者混合淋巴细胞培养反应(MLR)阻断抗体均为阴性。结果接受配偶、男性第三方或女性第三方淋巴细胞的患者妊娠率分别为85.6%、87.3%、89.7%和79.3%(P=0.523)，活产率分别为87.3%、75.8%、84.6%和40.5%(P<；结论女性第三方淋巴细胞可用于反复自然流产患者的免疫治疗。
Objectives Allogeneic lymphocytes of paternal origin or supplied by a male third party have been used for the treatment of recurrent spontaneous abortion. Few studies, however, have examined the use of female third party lymphocytes. Our purpose was to determine whether female third party lymphocytes could be used for immunotherapy of women with recurrent spontaneous abortion.Methods In this retrospective non-randomised cohort-controlled study, the medical records of patients with three or more spontaneous abortions who received immunotherapy with lymphocytes from their partner, a male third party or a female third party, as well as those who received no immunotherapy, from 1996 to 2012 were reviewed. All patients were negative for mixed lymphocyte culture reaction (MLR)-blocking antibodies. Immunotherapy was performed in 302 patients in two courses, while 53 patients received no immunotherapy.Results The pregnancy rates in patients who received lymphocytes from their partners, a male third party or a female third party, and in those not immunised, were 85.6%, 87.3%, 89.7%, and 79.3%, respectively (p = 0.523);the live birth rates were 87.3%, 75.8%, 84.6%, and 40.5%, respectively (p < 0.001).Conclusions We conclude that female third party lymphocytes can be used for immunotherapy in patients with recurrent spontaneous abortion.