N-3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes.: Implications in cardiac hypertrophy and heart failure
N-3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes.: Implications in cardiac hypertrophy and heart failure
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DOI：
10.1016/j.febslet.2007.01.070
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发表时间：
2007-03-06
期刊：
影响因子：
3.5
通讯作者：
Pession, Annalisa
中科院分区：
文献类型：
--
作者：
Bordoni, Alessandra;Astolfi, Annalisa;Pession, Annalisa
在心肌细胞中，n-3多不饱和脂肪酸对整个基因组的影响尚不清楚，尽管它们具有公认的心脏保护作用和调节基因表达的能力。我们研究了n-3PUFAs对培养的新生大鼠心肌细胞整体基因表达谱的影响，并在上调的心肌细胞中检测到了许多与脂质转运和代谢相关的基因。许多下调的基因似乎与炎症、细胞生长、细胞外和心脏基质重塑、钙运动和ROS生成有关。我们的数据允许推测n-3PUFAs的心脏保护作用与心肌细胞中基因的直接调控有关。(C)2007年欧洲生化学会联合会。爱思唯尔出版，版权所有。
In cardiac cells the effects of n - 3 PUFAs on the whole genome are still unknown despite their recognized cardio-protective effects and ability to modulate gene expression. We have evaluated the effects of n - 3 PUFAs supplementation on the global gene expression profile in cultured neonatal rat cardiomyocytes, detecting many genes related to lipid transport and metabolism among the upregulated ones. Many of the downregulated genes appeared related to inflammation, cell growth, extracellular and cardiac matrix remodelling, calcium movements and ROS generation. Our data allow to speculate that the cardioprotective effect of n - 3 PUFAs is related to a direct modulation of genes in cardiac cells. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.