Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains
Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains
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DOI：
10.1016/j.gene.2005.07.045
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发表时间：
2006-02-01
期刊：
影响因子：
3.5
通讯作者：
Lee, B
中科院分区：
文献类型：
--
作者：
Hahn, Y;Bera, TK;Lee, B
POTE家族基因编码含有锚蛋白重复序列和卷曲螺旋结构域的灵长类动物特异性蛋白的高度同源组。在8条人类染色体（2、8、13、14、15、18、21和22）上发现至少13个旁系同源的POTE家族基因，基于序列相似性可以将其分为3组。我们通过数据库搜索发现了一组额外的人类锚蛋白重复结构域蛋白，其中ANKRD 26和ANKRD 30 A的特征最好;这些是POTE家族蛋白的更远的同源物。基因组结构的全面比较表明，ANKRD 26具有ANKRD 30 A和所有POTE家族基因的可能祖先的基因组结构。在祖先基因的原始复制之后，涉及节段性丢失和内部复制的广泛重塑似乎重塑了ANKPD 30 A和POTE家族基因。我们还鉴定了人类ANKRD 26的小鼠同源物，但未能找到具有任何POTE家族蛋白质结构特征的小鼠同源物。小鼠Ankrd 26可作为研究人ANKRD 26、ANKRD 30 A和POTE家族蛋白功能的有用模型。(c)2005 Elsevier B. V.保留所有权利。
The POTE family genes encode a highly homologous group of primate-specific proteins that contain ankyrin repeats and coiled coil domains. At least 13 paralogous POTE family genes are found on 8 human chromosomes (2, 8, 13, 14, 15, 18, 21 and 22), which can be sorted into 3 groups based on sequence similarity. We identified by a database search a group of additional human ankyrin repeat domain proteins, of which ANKRD26 and ANKRD30A are the best characterized; these are more distant homologs of POTE family proteins. A comprehensive comparison of the genomic organization indicates that ANKRD26 has the genomic structure of the possible ancestor of ANKRD30A and all POTE family genes. Extensive remodeling involving segmental loss and internal duplication appears to have reshaped the ANKPD30A and POTE family genes after the primal duplication of the ancestor gene. We also identified a mouse homolog of human ANKRD26, but failed to find a mouse homolog that bears the structural characteristics of any of the POTE family of proteins. The mouse Ankrd26 may serve as a useful model for the study of the function of human ANKRD26, ANKRD30A and POTE family proteins. (c) 2005 Elsevier B.V. All rights reserved.