Association between vitamin D and bone mineral density in Japanese adults: the Unzen study
Association between vitamin D and bone mineral density in Japanese adults: the Unzen study
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日本成年人维生素 D 与骨矿物质密度之间的关联：云仙研究
DOI：
10.1007/s11657-021-00984-9
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发表时间：
2021
影响因子：
3
通讯作者：
Aoyagi Kiyoshi
中科院分区：
文献类型：
--
作者：
Honda Yuzo;Arima Kazuhiko;Nishimura Takayuki;Tomita Yoshihito;Mizukami Satoshi;Abe Yasuyo;Tanaka Natsumi;Kojima Michiko;Jeng Tsung-Ping;Goto Hisashi;Hasegawa Maiko;Sou Youko;Tsujimoto Ritsu;Kanagae Mitsuo;Osaki Makoto;Aoyagi Kiyoshi
总结我们显示了在调整混杂因素后，日本社区居民成年人血清维生素D浓度与骨骼健康之间的相关性，一个城市有730名参与者，25（OH）维生素D浓度，目的探讨血清25-羟维生素D（25（OH）D）水平与超声定量参数的相关性。浓度和骨指标，如通过定量超声在夏季和秋季期间生活在低纬度海滨地区的中年和老年日本成年人中测量的。2011年至2013年期间参加定期健康检查的社区居住日本成年人结果共有301名男性（平均（SD）年龄，67.9（8.2）岁;范围，50-92岁）和429名女性（平均（SD）年龄，67.9（7.7）岁;范围，50-89岁）参加了这项研究。测量受试者的血清25（OH）D水平和定量超声参数（宽带超声（BUA）、声速（SOS）和跟骨硬度指数）。我们从730名参与者中排除了2名男性和28名女性，因为他们正在接受骨质疏松症药物治疗。因此，299名男性和401名女性被纳入最终数据分析。维生素D不足（< 30 ng/ml）的患病率非常高：男性为71.9%，女性为95.5%。在女性中，log（25（OH）D）与SOS（p= 0.011）和僵硬指数（p= 0.028）呈显著正相关，但与BUA（p= 0.176）无关。在男性中，log（25（OH）D）与BUA，SOS，或刚度指数（p= 0.218，0.420，和0.262，分别）。
SummaryWe showed an association between serum concentrations of vitamin D and bone health among community-dwelling adults in Japan after adjustment for confounding factors, with 730 participants in a city, with concentrations of 25(OH) vitamin D, and with parameters of quantitative ultrasound.PurposeThe primary objective of this study was to examine the correlation between serum 25-hydroxyvitamin D (25(OH)D) concentration and bone indicators as measured by quantitative ultrasound in middle-aged and older Japanese adults living in low-latitude seaside areas during summer and autumn.MethodsWe conducted a cross-sectional study, the Unzen study, on community-dwelling Japanese adults who participated to periodic health examinations between 2011 and 2013 (during the months of May to November).ResultsA total of 301 men (mean (SD) age, 67.9 (8.2) years; range, 50–92 years) and 429 women (mean (SD) age, 67.9 (7.7); range, 50–89 years) participated in this study. Serum 25(OH)D levels and quantitative ultrasound parameters (broadband ultrasound (BUA), speed of sound (SOS), and stiffness index of the calcaneus were measured for the participants. We excluded two men and 28 women from the 730 participants because they were on medication for osteoporosis. So, 299 men and 401 women were included in the final data analysis. The prevalence of vitamin D insufficiency (< 30 ng/ml) was very high: 71.9% in men and 95.5% in women. In women, the log(25(OH)D) positively and significantly correlated with SOS (p= 0.011) and stiffness index (p= 0.028) but not with BUA (p= 0.176). In men, the log(25(OH)D) did not correlate with the BUA, SOS, or stiffness index (p= 0.218, 0.420, and 0.262, respectively).ConclusionsSerum 25(OH)D levels were associated with SOS or stiffness index in women but not in men.