Stability of retrieved memory: Inverse correlation with trace dominance
Stability of retrieved memory: Inverse correlation with trace dominance
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DOI：
10.1126/science.1086881
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发表时间：
2003-08-22
期刊：
影响因子：
56.9
通讯作者：
Dudai, Y
中科院分区：
文献类型：
--
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
在记忆巩固过程中，记忆痕迹稳定下来，并对某些遗忘剂产生抵抗力。教科书上的说法是，对于任何记忆的项目，巩固的开始和结束只有一次。然而，越来越多的证据表明，一旦激活提取，痕迹可能会重新巩固。虽然一些作者报道短暂的恢复敏感性的记忆巩固blocker，其他人不能检测到it.Here，我们报告说，在条件性味觉厌恶的大鼠和恐惧条件的青鳉鱼，检索记忆的稳定性是负相关的行为控制的记忆。这个结果可以解释一些相互矛盾的发现激活记忆的再巩固。
In memory consolidation, the memory trace stabilizes and becomes resistant to certain amnesic agents. The textbook account is that for any memorized item, consolidation starts and ends just once. However, evidence has accumulated that upon activation in retrieval, the trace may reconsolidate. Whereas some authors reported transient renewed susceptibility of retrieved memories to consolidation blockers, others could not detect it. Here, we report that in both conditioned taste aversion in the rat and fear conditioning in the medaka fish, the stability of retrieved memory is inversely correlated with the control of behavior by that memory. This result may explain some conflicting findings on reconsolidation of activated memories.