A Schistosomiasis Model with Praziquantel Resistance
A Schistosomiasis Model with Praziquantel Resistance
复制标题
具有吡喹酮耐药性的血吸虫病模型
DOI：
10.1155/2013/945767
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发表时间：
2013-01-01
影响因子：
1.4
通讯作者：
Cui, Jing-an
中科院分区：
文献类型：
--
作者：
Qi, Longxing;Cui, Jing-an
建立了血吸虫病吡喹酮抗药性的房室模型。该模型考虑了遗传抗性和药物治疗对血吸虫病传播的影响。计算了基本再生数，讨论了无病平衡点、边界平衡点和共存平衡点的存在性和稳定性。我们的分析表明，无论药物治疗是否导致耐药性的出现，一旦遗传耐药性的影响较大，耐药菌株将占优势，这对血吸虫病的控制不利。此外，一旦药物治疗产生耐药菌株的人的比例较大，则耐药菌株的人和螺的数量也较大。这对于吡喹酮的药物治疗不是一个好的结果。
A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless of whether drug treatment leads to the emergence of resistance, once the impact of genetic resistance is larger, the resistant strain will be dominant, which is detrimental to the control of schistosomiasis. In addition, once the proportion of human with drug-resistant strain produced by drug treatment is larger, the number of human and snails with resistant strain is larger. This is not a good result for drug treatment with praziquantel.