Anticancer drugs from marine flora: an overview.
Anticancer drugs from marine flora: an overview.
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DOI：
10.1155/2010/214186
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发表时间：
2010
影响因子：
--
通讯作者：
Kathiresan K
中科院分区：
文献类型：
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作者：
Sithranga Boopathy N;Kathiresan K
细菌、放线菌、蓝藻、真菌、微藻、海藻、红树林等海洋植物群是极其重要的海洋资源，占海洋生物量的90%以上。它们在分类上多样化，高产，生物活性和化学上独特，为发现新的抗癌药物提供了很大的空间。海洋植物群富含药用化学物质，主要属于多酚类和硫酸多糖。这些化学物质显示出一系列的药理学特性，特别是抗氧化、免疫刺激和抗肿瘤活性。这些植物化学物质可能激活巨噬细胞，诱导细胞凋亡，防止DNA氧化损伤，从而控制癌变。尽管蕴藏着丰富的化学物质资源，但海洋植物群中抗癌先导化合物的研究在很大程度上尚未得到开发。因此，本文综述了迄今为止在这方面开展的工作，以期在癌症发病率不断上升，缺乏更便宜、更安全、更有效的药物来挑战可怕的人类疾病的背景下，为促进基于海洋植物群的抗癌研究提供基线信息。
Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the oceanic biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.