Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence
Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence
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DOI：
10.1073/pnas.93.12.6140
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发表时间：
1996-06-11
影响因子：
11.1
通讯作者：
Hughes, KA
中科院分区：
文献类型：
--
作者：
Charlesworth, B;Hughes, KA
衰老进化的两大理论（突变积累和拮抗多效性）对年龄、近交效应和生活史分量的遗传方差分量的大小之间的关系作出了不同的预测。我们表明，在随机交配群体中，在突变积累下，近交衰退和遗传方差的三个主要分量预计将随年龄的增加而增加，在最简单的拮抗多效性模型下，预期近交衰退的严重程度、显性方差或染色体纯合子的遗传方差没有变化，但加性遗传方差可能随年龄增加。使用从黑腹果蝇种群中提取的品系，对于这两个性状，近交下降和遗传方差的几个组成部分随着年龄的增长，结果是一致的突变积累模型，但只能解释为拮抗多效性，如果有一个普遍的趋势，随着年龄的增长，这些生活史性状的等位基因效应的大小。
Two major theories of the evolution of senescence (mutation accumulation and antagonistic pleiotropy) make different predictions about the relationships between age, inbreeding effects, and the magnitude of genetic variance components of life-history components, We show that, under mutation accumulation, inbreeding decline and three major components of genetic variance are expected to increase with age in randomly mating populations, Under the simplest version of the antagonistic pleiotropy model, no changes in the severity of inbreeding decline, dominance variance, or the genetic variance of chromosomal homozygotes are expected, but additive genetic variance may increase with age, Age-specific survival rates and mating success were measured on virgin males, using lines extracted from a population of Drosophila melanogaster, For both traits, inbreeding decline and several components of genetic variance increase with age, The results are consistent with the mutation accumulation model, but can only be explained by antagonistic pleiotropy if there is a general tendency for an increase with age in the size of allelic effects on these life-history traits.