Dynamic Functional Connectivity between order and randomness and its evolution across the human adult lifespan
Dynamic Functional Connectivity between order and randomness and its evolution across the human adult lifespan
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DOI：
10.1016/j.neuroimage.2020.117156
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发表时间：
2020-11-15
期刊：
影响因子：
5.7
通讯作者：
Jirsa, Viktor
中科院分区：
文献类型：
--
作者：
Battaglia, Demian;Boudou, Thomas;Jirsa, Viktor
功能连接（FC）在休息状态或任务条件下不是静态的，而是固有的动态。然而，有没有共识，在FC的波动可能类似于离散FC状态之间的孤立过渡，而不是连续的变化。这一争论阻碍了动态模糊控制理论研究的深入。这是不幸的，因为FC的波动结构肯定可以提供更多关于发育变化、衰老和病理进展的信息。我们合并这两个角度，并考虑动态FC作为一个正在进行的网络重构，包括可能的稳定FC状态的空间的随机探索。这种随机游走的统计特性既偏离了纯粹的“订单驱动”的动态，其中平均FC被保存，也偏离了纯粹的“随机驱动”的情况，其中FC的波动随着时间的推移保持不相关。相反，动态FC具有一个复杂的结构，赋予长范围的顺序相关性，引起瞬态减速和加速时期的连续流的重新配置。我们对健康老年人的fMRI数据的分析表明，随着年龄的增长，动态FC趋于减慢，变得不那么复杂，也更随机。这些影响似乎与行为和认知能力的年龄相关变化密切相关。
Functional Connectivity (FC) during resting-state or task conditions is not static but inherently dynamic. Yet, there is no consensus on whether fluctuations in FC may resemble isolated transitions between discrete FC states rather than continuous changes. This quarrel hampers advancing the study of dynamic FC. This is unfortunate as the structure of fluctuations in FC can certainly provide more information about developmental changes, aging, and progression of pathologies. We merge the two perspectives and consider dynamic FC as an ongoing network reconfiguration, including a stochastic exploration of the space of possible steady FC states. The statistical properties of this random walk deviate both from a purely "order-driven" dynamics, in which the mean FC is preserved, and from a purely "randomness-driven" scenario, in which fluctuations of FC remain uncorrelated over time. Instead, dynamic FC has a complex structure endowed with long-range sequential correlations that give rise to transient slowing and acceleration epochs in the continuous flow of reconfiguration. Our analysis for fMRI data in healthy elderly revealed that dynamic FC tends to slow down and becomes less complex as well as more random with increasing age. These effects appear to be strongly associated with age-related changes in behavioural and cognitive performance.