The complete genome sequence of Propionibacterium acnes, a commensal of human skin
The complete genome sequence of Propionibacterium acnes, a commensal of human skin
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DOI：
10.1126/science.1100330
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发表时间：
2004-07-30
期刊：
影响因子：
56.9
通讯作者：
Gottschalk, G
中科院分区：
文献类型：
--
作者：
Brüggemann, H;Henne, A;Gottschalk, G
痤疮丙酸杆菌是成人皮肤的主要居民，它存在于皮脂腺毛囊内，通常作为一种无害的共生菌，尽管它与寻常性痤疮的形成有关。该革兰氏阳性菌的全基因组序列编码2333个假定基因，并揭示了许多参与降解宿主分子的基因产物，包括唾液酸酶、神经氨酸酶、内糖神经酰胺酶、脂肪酶和孔隙形成因子。表面相关和其他免疫原性因素已被确定，这可能涉及触发痤疮炎症和其他痤疮相关疾病。
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.