PRINCIPLES OF LOCOMOTION FOR SIMPLE-SHAPED CELLS
PRINCIPLES OF LOCOMOTION FOR SIMPLE-SHAPED CELLS
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DOI：
10.1038/362167a0
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发表时间：
1993-03-11
期刊：
影响因子：
64.8
通讯作者：
JACOBSON, K
中科院分区：
文献类型：
--
作者：
LEE, J;ISHIHARA, A;JACOBSON, K
运动的细胞表现出各种各样的形状和运动模式，但尚不清楚分子水平上的运动如何与整个细胞的运动联系起来，这是一个复杂形状细胞研究中的问题。鱼类表皮角化细胞运动的一个显著特征是其明显的简单性。在这里，我们提出了运动的运动学描述，这与鱼表皮角质细胞的半圆形和持续的“滑行”运动是一致的。我们认为这些细胞前部的伸展和后部的收缩是垂直于细胞边缘发生的，并且沿着细胞边缘的伸展和收缩速率的梯度分布在运动过程中保持了细胞的形状和大小。这种描述的证据来自于预测的层状特征的周向运动，以及在移动的角化细胞的特定分子成分中“照片标记”线的曲率。我们的描述将分子组合的动力学与整个细胞的运动联系起来。
MOVING cells display a variety of shapes and modes of locomotion1, but it is not clear how motility at the molecular level relates to the locomotion of a whole cell, a problem compounded in studies of cells with complex shapes2-5. A striking feature of fish epidermal keratocyte locomotion is its apparent simplicity6. Here we present a kinematic description of locomotion which is consistent with the semicircular shape and persistent 'gliding' motion of fish epidermal keratocytes. We propose that extension of the front and retraction of the rear of these cells occurs perpendicularly to the cell edge, and that a graded distribution of extension and retraction rates along the cell margin maintains cell shape and size during locomotion. Evidence for this description is provided by the predicted circumferential motion of lamellar features and the curvature of 'photo-marked' lines within specific molecular components of moving keratocytes. Our description relates the dynamics of molecular assemblies to the movement of a whole cell.