A microfluidic device for conducting gas-liquid-solid hydrogenation reactions
A microfluidic device for conducting gas-liquid-solid hydrogenation reactions
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DOI：
10.1126/science.1096956
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发表时间：
2004-05-28
期刊：
影响因子：
56.9
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Kobayashi, J;Mori, Y;Kobayashi, S
我们已经开发了一个有效的系统，三相反应使用微通道反应器。使用该系统，我们进行了氢化反应，顺利进行，在2分钟内定量提供各种底物的所需产物。该体系也可应用于脱保护反应。我们可以实现氢，基板，和钯催化剂之间的有效相互作用，使用非常大的界面面积和分子扩散所需的短路径在非常狭窄的通道空间。这一概念可以扩展到其他使用气相试剂（如氧气和二氧化碳）的多相反应。
We have developed an efficient system for triphase reactions using a micro-channel reactor. Using this system, we conducted hydrogenation reactions that proceeded smoothly to afford the desired products quantitatively within 2 minutes for a variety of substrates. The system could also be applied to deprotection reactions. We could achieve an effective interaction between hydrogen, substrates, and a palladium catalyst using extremely large interfacial areas and the short path required for molecular diffusion in the very narrow channel space. This concept could be extended to other multiphase reactions that use gas-phase reagents such as oxygen and carbon dioxide.