IN-VIVO F-19 MR-IMAGING - RELAXATION ENHANCEMENT WITH GD-DTPA
IN-VIVO F-19 MR-IMAGING - RELAXATION ENHANCEMENT WITH GD-DTPA
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DOI：
10.1002/jmri.1880040416
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发表时间：
1994-07-01
期刊：
影响因子：
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通讯作者：
CACHERIS, WP
中科院分区：
文献类型：
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作者：
LEE, H;PRICE, RR;CACHERIS, WP
磁共振 (MR) 成像中缺乏自然产生的氟背景信号，这使得氟化化合物成为组织特异性 MR 造影剂的潜在候选者。与体内使用氟化化合物相关的问题是毒性，这限制了可以使用的试剂的量；多条共振线； T1 过长，导致序列 TR 较长，从而导致成像时间较长。许多氟化剂还具有复杂的磁共振光谱，如果不加以校正，会导致化学位移伪影。作者展示了使用具有单 MR 峰的细胞外氟化剂对动物模型中的脑脓肿进行选择性成像，并表明通过使用 T1 弛豫剂二亚乙基三胺五乙酸钆 (DTPA) 可以增强每单位采集时间的图像信号。以氟19剂量4 mmol/kg给予三氟甲基磺酸，并在注射标准剂量Gd-DTPA（0.1 mmol/kg）前后获取诱发脓肿的氟图像；使用非部分选择的投影图像。典型的成像时间少于 5 分钟。使用 500/12（TR 毫秒/TE 毫秒）自旋回波序列实现的信号增强因子约为四 (4.0 +/- 0.8)。
The lack of a naturally occurring background signal from fluorine in magnetic resonance (MR) imaging makes fluorinated compounds potentially attractive candidates for tissue-specific MR contrast agents. Problems associated with the in vivo use of fluorinated compounds are toxicity, which limits the amount of agent that can be used; multiple resonance lines; and an excessively long T1, which leads to long sequence TRs and consequently long imaging times. Many fluorinated agents also possess complex MR spectra that result in chemical shift artifacts if not corrected. The authors demonstrate the use of an extracellular fluorinated agent with a single MR peak for selective imaging of a brain abscess in an animal model and show that the image signal per unit of acquisition time can be enhanced through the use of a T1 relaxation agent, gadolinium diethylenetriamine-pentaacetic acid (DTPA). Trifluoromethylsulfonate was administered at a fluorine-19 dose of 4 mmol/kg, and fluorine images of the induced abscess were acquired before and after the injection of a standard dose of Gd-DTPA (0.1 mmol/kg); non-section-selected projection images were used. Typical imaging times were less than 5 minutes. The signal enhancement factor achieved was approximately four (4.0 +/- 0.8) with use of a 500/12 (TR msec/TE msec) spin-echo sequence.