Pathogenic and antimicrobial resistance genes in Streptococcus oralis strains revealed by comparative genome analysis
Pathogenic and antimicrobial resistance genes in Streptococcus oralis strains revealed by comparative genome analysis
复制标题
通过比较基因组分析揭示口腔链球菌菌株中的致病性和抗菌药物耐药性基因
DOI：
10.1016/j.ygeno.2020.04.014
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发表时间：
2020
期刊：
影响因子：
4.4
通讯作者：
Feng Qiang
中科院分区：
文献类型：
--
作者：
Zhou Jiannan;Sun Tianyong;Kang Wenyan;Tang Di;Feng Qiang
口腔链球菌是牙菌斑中的早期定植菌，被认为是感染性心内膜炎（IE）疾病的潜在病原体。本研究构建了口腔链球菌SOT株、口腔链球菌SOD株和婴儿链球菌SO株的全基因组图谱，并对这三株链球菌进行了比较基因组分析。结果表明，SOT菌株存在5个基因组岛，SOD菌株存在1个CRISPR基因组岛。每个基因组都含有多种与疾病和耐药性相关的致病基因，而SOT和SOD菌株的耐药基因与SO菌株的耐药基因非常相似，但又存在差异。此外，我们还鉴定了3个菌株的17个主要毒力因子和荚膜相关基因。提示口腔链球菌具有致病潜力，为口腔链球菌感染的防治奠定了基础。
Streptococcus oralis is an early colonizer bacterium in dental plaques and is considered a potential pathogen of infective endocarditis (IE) disease. In this study, we built a complete genome map ofStreptococcus oralisstrain SOT,Streptococcus oralisstrain SOD andStreptococcus infantisstrain SO and performed comparative genomic analysis among these three strains. The results showed that there are five genomic islands (GIs) in strain SOT and one CRISPR in strain SOD. Each genome harbors various pathogenic genes related to diseases and drug resistance, while the antibiotic resistance genes in strains SOT and SOD were quite similar but different from those in strain SO. In addition, we identified 17 main virulence factors and capsule-related genes in three strains. These results suggest the pathogenic potential ofStreptococcusstrains, which lay a foundation for the prevention and treatment of aStreptococcus oralisinfection.