ROLE OF SENSORY NERVE ENDINGS IN NEUROGENIC INFLAMMATION INDUCED IN HUMAN SKIN AND IN EYE AND PAW OF RAT
ROLE OF SENSORY NERVE ENDINGS IN NEUROGENIC INFLAMMATION INDUCED IN HUMAN SKIN AND IN EYE AND PAW OF RAT
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DOI：
10.1111/j.1476-5381.1968.tb00471.x
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发表时间：
1968-01-01
影响因子：
7.3
通讯作者：
SZOLCSAN.J
中科院分区：
文献类型：
--
作者：
JANCSO, N;JANCSOGA.A;SZOLCSAN.J
辣椒素、芥子油、二甲苯或[omega]-氯苯乙酮在大鼠眼部或爪部引起的神经源性炎症不能被局部麻醉抑制，但如前所述，可以通过感觉去神经或辣椒素脱敏来预防。在失去神经的人皮肤上，可以证明辣椒素完全发挥了作用，而芥子油或二甲苯主要是通过神经性途径发挥作用的。组胺、化合物48/80[对甲氧基苯基甲胺和甲醛的缩合产物]和烟酸羟甲酯(曲呋利)的炎症作用在很大程度上独立于神经机制，但在人类皮肤局部麻醉中参与其作用的神经因素可防止由神经原性作用刺激物引起的炎症反应的耀斑成分，而不影响对接触部位的直接影响。提出的假设是，在神经源性炎症中，一种增加通透性的神经体液从感觉神经末梢释放出来，这是局部麻醉无法阻断的。在人类皮肤中，神经体液的释放发生在轴突反射弧的两端。
The neurogenic inflammation induced by capsaicin, mustard oil, xylene or [omega]-chloroacetophenone in the eye or paw of the rat is not inhibited by local anesthesia, but, as previously shown, can be prevented by sensory denervation or capsaicin desensitization. In denervated human skin it could be proved that capsaicin exerts its effect entirely, and mustard oil or xylene predominantly by a neurogenic route. The inflammatory effects of histamine, compound 48/80 [condensation product of p-methoxyphenylmethylamine and formaldehyde] and thurfyl nicotinate (Trafuril) are largely independent of a neural mechanism but neural factors contribute to it In human skin local anesthesia prevents the flare component of the inflammatory reaction induced by neurogenically acting irritants, without affecting the direct effect on the site of contact. The hypothesis is put forward that in neurogenic inflammation a neurohumor which increases permeability is released from sensory nerve terminals which cannot be blocked by local anesthesia. In human skin release of the neurohumor occurs at both terminals of the axon reflex arc.