The whole body cryostimulation modifies irisin concentration and reduces inflammation in middle aged, obese men
The whole body cryostimulation modifies irisin concentration and reduces inflammation in middle aged, obese men
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DOI：
10.1016/j.cryobiol.2015.10.143
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发表时间：
2015-12-01
期刊：
影响因子：
2.7
通讯作者：
Ziemann, Ewa
中科院分区：
文献类型：
--
作者：
Dulian, Katarzyna;Laskowski, Radoslaw;Ziemann, Ewa
低温诱导的抗炎作用可能触发肌肉和脂肪组织的内分泌功能。因此，本研究的目的是研究全身冷冻刺激（CRY）对鸢尾素的影响，鸢尾素是一种激活脂肪细胞耗氧和产热的肌肉因子。此外，还研究了调节铁代谢的hepcidin （Hpc）激素与炎症的关系。一组中年男性（n = 12, 38 +/- 9岁，BMI > - 30 kg m(-2)）参与研究。受试者在低温室中连续10次暴露（每天1次，上午9:30，持续3分钟，温度为110摄氏度）。在第一次冷冻刺激前和完成最后一次冷冻刺激后采集血样。治疗前测定体成分和健康水平。应用冷冻刺激方案导致肥胖非运动男性血中鸢尾素升高（338.8 +/- 42.2 vs 407.6 +/- 118.5 ng mL(-1)），而对肥胖运动男性没有影响（371.5 +/- 30.0 vs 3433 +/- 47.6 ng mL(-1)）。最后一次冷冻24小时后记录的数值与脂肪组织显著相关，而与骨骼肌质量呈负相关。因此，我们得出结论，皮下脂肪组织是应对寒冷暴露的鸢尾素的主要来源。冷处理降低了高敏c反应蛋白（hsCRP）和Hpc浓度，证实了其抗炎作用。(C) 2015爱思唯尔公司版权所有。
The anti-inflammatory effect induced by exposure to low temperature might trigger the endocrine function of muscle and fat tissue. Thus, the aim of this study was to investigate the influence of the whole body cryostimulation (CRY) on irisin, a myokine which activates oxygen consumption in fat cells as well as thermogenesis. In addition, the relationship between hepcidin (Hpc) hormone regulating iron metabolism, and inflammation was studied.A group of middle aged men (n = 12, 38 +/- 9 years old, BMI > 30 kg m(-2)) participated in the study. Subjects were exposed to a series of 10 sessions in a cryogenic chamber (once a day at 9:30 am, for 3 min, at temperature 110 degrees C). Blood samples were collected before the first cryostimulation and after completing the last one. Prior to treatment body composition and fitness level were determined. The applied protocol of cryostimulation lead to rise the blood irisin in obese non-active men (338.8 +/- 42.2 vs 407.6 +/- 118.5 ng mL(-1)), whereas has no effect in obese active men (371.5 +/- 30.0 vs 3433 +/- 47.6 ng mL(-1)). Values recorded 24 h after the last cryo-session correlated significantly with the fat tissue, yet inversely with the skeletal muscle mass. Therefore, we concluded the subcutaneous fat tissue to be the main source of irisin in response to cold exposures. The applied cold treatment reduced the high sensitivity C-reactive protein (hsCRP) and Hpc concentration confirming its anti-inflammatory effect. (C) 2015 Elsevier Inc. All rights reserved.