CYCLIC-AMP AS A 2ND MESSENGER IN HIGHER-PLANTS - STATUS AND FUTURE-PROSPECTS
CYCLIC-AMP AS A 2ND MESSENGER IN HIGHER-PLANTS - STATUS AND FUTURE-PROSPECTS
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DOI：
10.1104/pp.108.3.885
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发表时间：
1995-07-01
期刊：
影响因子：
7.4
通讯作者：
ASSMANN, SM
中科院分区：
文献类型：
--
作者：
ASSMANN, SM
腺苷 3':5'-一磷酸，通常称为 cAMP，是从盘基网柄菌到智人等生物体中的关键第二信使。 cAMP 最初被描述为肝脏中糖原分解的调节剂，现在已知它是动物体内多种细胞反应的第二信使。 cAMP 是通过腺苷酸环化酶的作用从 ATP 产生的，并被 cAMP 磷酸二酯酶水解为 AMP。几十年来，cAMP 是否是高等植物中真正的第二信使的问题一直困扰着植物科学家。本文将重点介绍围绕 cAMP 的争议的各个方面，并提出解决这些争议的步骤。文献引用主要限于过去 5 年，因为早期的工作已在几篇评论中进行了总结。
Adenosine 3':5'-monophosphate, commonly known as cAMP, is a key second messenger in living organisms ranging from Dictyostelium to Home sapiens. cAMP was first described as a regulator of glycogen breakdown in the liver and is now known to be a second messenger for a wide variety of cellular responses in animals. cAMP is produced from ATP by the action of adenylate cyclase and is hydrolyzed to AMP by the enzyme cAMP phosphodiesterase.The question of whether cAMP is an authentic second messenger in higher plants has engaged plant scientists for decades. This article will highlight aspects of the controversies surrounding cAMP and suggest steps toward their possible resolution. Literature citations are largely restricted to the last 5 years, since earlier work has been summarized in several reviews.