GASTROINTESTINAL ABSORPTION OF CALCIUM FROM MILK AND CALCIUM SALTS
GASTROINTESTINAL ABSORPTION OF CALCIUM FROM MILK AND CALCIUM SALTS
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DOI：
10.1056/nejm198708273170903
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发表时间：
1987-08-27
影响因子：
158.5
通讯作者：
FORDTRAN, JS
中科院分区：
文献类型：
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作者：
SHEIKH, MS;SANTAANA, CA;FORDTRAN, JS
从水溶性钙盐中摄取的钙是否比从难溶性钙盐中摄取的钙更有效尚不清楚。目前还不清楚钙是否从乳制品中比从钙盐中更好地吸收。使用一种方法，通过该方法可以准确地测量单次给药后钙的净吸收，我们研究了8名健康的空腹受试者，他们分别从具有不同水溶性程度的五种钙盐和牛奶中摄取了500 mg剂量的钙。另一种给药方式随机确定。平均值（.+-. SEM）的净钙吸收，按盐的溶解度递减的顺序，为32 ± 1。4%来自乙酸钙，32. ±. 4%来自乳酸钙，27. ±. 3%来自葡萄糖酸钙，30. ±. 3%来自柠檬酸钙，39. ±. 3%来自碳酸钙。根据方差分析，吸收差异无统计学意义。在体外溶解度实验的基础上，在酸性介质中，我们假设，酸溶解胃肠道可能是负责从盐具有广泛不同的水溶解度的钙的类似吸收。从全脂牛奶中吸收的钙（31.+-. 3%）与钙盐的吸收相似。我们的结论是，钙的碳酸盐，醋酸盐，乳酸盐，葡萄糖酸盐和柠檬酸盐的钙吸收，从全脂牛奶中，空腹健康的年轻人是相似的。需要进一步研究以确定结果是否在年龄较大的受试者中不同，使用较高剂量的钙，或者如果钙与食物一起摄入。
Whether ingested calcium is absorbed more efficiently from freely water-soluble calcium salts than from poorly soluble salts is unclear. It is also unknown whether calcium is absorbed better from dairy products than from calcium salts. Using a method by which the net absorption of calcium can be accurately measured after a single dose, we studied eight healthy fasting subjects after they took a 500-mg dose of calcium from each of five calcium salts with various degrees of water solubility and from milk. The other of administration of the agents given was randomly determined. The mean (.+-. SEM) net calcium absorption, in decreasing order of the solubility of the salts, was 32 .+-. 4 percent from calcium acetate, 32 .+-. 4 percent from calcium lactate, 27 .+-. 3 percent from calcium gluconate, 30 .+-. 3 percent from calcium citrate, and 39 .+-. 3 percent from calcium carbonate. The differences in absorption were not statistically significant according to analysis of variance. On the basis of in vitro solubility experiments in acid mediums, we hypothesize that acid dissolution the gastrointestinal tract may be responsible for the similar absorption of calcium from salts with widely different water solubilities. Calcium absorption from whole milk (31 .+-. 3 percent) was similar to absorption from calcium salts. We conclude that calcium absorption from carbonate, acetate, lactate, gluconate, and citrate salts of calcium, and from whole milk, is similar in fasting healthy young subjects. Further study will be required to determine whether the results would be different in older subjects, with a higher dose of calcium, or if the calcium was ingested with food.