Wiring nanoscale biosensors with piezoelectric nanomechanical resonators.
Wiring nanoscale biosensors with piezoelectric nanomechanical resonators.
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DOI：
10.1021/nl100245z
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发表时间：
2010-04
期刊：
影响因子：
10.8
通讯作者：
A. S. Sadek;R. Karabalin;Jiangang Du;M. Roukes;C. Koch;S. Masmanidis
中科院分区：
文献类型：
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作者：
A. S. Sadek;R. Karabalin;Jiangang Du;M. Roukes;C. Koch;S. Masmanidis
纳米级集成电路和传感器将需要与宏观世界不显眼地互连的方法，以充分发挥其潜力。我们报告了一种纳米机电系统，它可以通过使来自多站点传感器的信息多路复用到单个输出线上来解决布线问题。该方法的基础是由压电耦合纳米级谐振器介导的机械傅立叶变换。我们的技术允许对任何电压敏感设备的电势进行敏感、线性和实时测量。用这种方法，我们证明了神经元动作电位的直接转导来自细胞外微电极。这种连接纳米级设备的方法可能会导致具有数千个通道的微创植入式传感器，用于体内神经元记录、医学诊断和电化学传感。
Nanoscale integrated circuits and sensors will require methods for unobtrusive interconnection with the macroscopic world to fully realize their potential. We report on a nanoelectromechanical system that may present a solution to the wiring problem by enabling information from multisite sensors to be multiplexed onto a single output line. The basis for this method is a mechanical Fourier transform mediated by piezoelectrically coupled nanoscale resonators. Our technique allows sensitive, linear, and real-time measurement of electrical potentials from conceivably any voltage-sensitive device. With this method, we demonstrate the direct transduction of neuronal action potentials from an extracellular microelectrode. This approach to wiring nanoscale devices could lead to minimally invasive implantable sensors with thousands of channels for in vivo neuronal recording, medical diagnostics, and electrochemical sensing.