Qualitative inquiry into perceptions of HIV pre-exposure prophylaxis among people who inject drugs living with hepatitis C in Seattle, WA, USA.
Qualitative inquiry into perceptions of HIV pre-exposure prophylaxis among people who inject drugs living with hepatitis C in Seattle, WA, USA.
复制标题
DOI：
10.1186/s12954-022-00706-5
复制
发表时间：
2022-11-01
影响因子：
4.4
通讯作者：
Tsui, Judith, I
中科院分区：
文献类型：
--
作者：
Barry, Michael P.;Austin, Elizabeth J.;Bhatraju, Elenore P.;Glick, Sara N.;Stekler, Joanne D.;Tung, Elyse L.;Hansen, Ryan N.;Williams, Emily C.;Gojic, Alexander J.;Pickering, Eleanor, I;Tsui, Judith, I
关键词：
自2014年以来，美国注射毒品者（PWID）的艾滋病毒发病率一直在上升，这表明需要确定有效的方法，使PWID参与艾滋病毒预防服务，即暴露前预防（PrEP）。然而，与其他有艾滋病毒感染风险的人群相比，这一人群对PrEP的吸收是最小的。在这项工作中，我们试图探索知识，态度，以及PWID之间的PrEP可接受性的观点。在一项探索基于药物的丙型肝炎病毒（HCV）治疗可接受性的试点研究中，我们对HCV感染者和报告主动注射药物使用（自上次使用后≤ 90天）的人进行了半结构化访谈（n = 24）和焦点小组（n = 4，16名参与者）。参与者被问到开放式的问题，他们熟悉和动机使用PrEP。作为子分析的一部分，专注于PrEP，定性数据进行了分析，使用快速评估过程，其中三个编码器使用结构化的模板来总结定性数据，并反复审查编码模板，以确定主题。参与者还完成了关于药物使用史和对健康问题的态度的简短定量问卷。47%的参与者表示很少或根本不担心艾滋病毒的感染。有针对性的分析侧重于艾滋病毒的预防确定了三个主题，这有助于描述行为的决定因素。首先，PrEP的知识在PWID中是有限的，并且受到围绕艾滋病毒风险的公开社区讨论的影响。第二，PWID认为性行为，而不是注射毒品的使用，作为一个动机，艾滋病毒的风险预防。最后，PWID确定了许多阻碍PrEP吸收的个人和环境障碍。在PWID中，PrEP很少被讨论，并且对使用每日PrEP的可行性的担忧是常见的。鉴于人们普遍认为吸毒对艾滋病毒感染风险不高，我们的研究结果指出，公共卫生工作有机会将PrEP教育针对PWID，并利用其他成功的PWID干预措施，为这一弱势群体提供PrEP。
The incidence of HIV among persons who inject drugs (PWID) in the USA has been increasing since 2014, signaling the need to identify effective ways to engage PWID in HIV prevention services, namely pre-exposure prophylaxis (PrEP). Yet, the uptake of PrEP in this population is minimal compared to other populations at risk of HIV acquisition. In this work, we sought to explore knowledge, attitudes, and perspectives of PrEP acceptability among PWID. In the context of a pilot study to explore the acceptability of pharmacy-based hepatitis C virus (HCV) treatment, we conducted semi-structured interviews (n = 24) and focus groups (n = 4, 16 participants) with people who were living with HCV and reported active injection drug use (≤ 90 days since last use). Participants were asked open-ended questions about their familiarity with and motivation to use PrEP. As part of a sub-analysis focused on PrEP, qualitative data were analyzed using a Rapid Assessment Process, where three coders used structured templates to summarize qualitative data and iteratively reviewed coded templates to identify themes. Participants also completed short quantitative questionnaires regarding drug use history and attitudes toward health concerns. Forty-seven percent of participants expressed having little or no concern regarding HIV acquisition. Targeted analyses focused on HIV prevention identified three themes, which help characterize behavioral determinants of nonadoption. First, knowledge of PrEP was limited among PWID and influenced by infrequent open community discussions around HIV risk. Second, PWID perceived sexual behaviors—but not injection drug use—as a motivator for HIV risk prevention. Finally, PWID identified many individual and environmental barriers that hinder PrEP uptake. Among PWID, PrEP is rarely discussed and concerns about the feasibility of using daily PrEP are common. Taken with the prevalent perception that drug use is not a high risk for HIV acquisition, our findings point to opportunities for public health work to target PrEP education to PWID and to leverage other successful interventions for PWID as an opportunity to provide PrEP to this vulnerable population.
登录
查看更多内容
影响因子：
33.9
作者：
Golden, Matthew R.;Lechtenberg, Richard;Buskin, Susan E.
通讯作者：
Buskin, Susan E.
影响因子：
11.8
作者：
Boerekamps, Anne;Newsum, Astrid M.;van der Valk, Marc
通讯作者：
van der Valk, Marc
影响因子：
168.9
作者：
Choopanya, Kachit;Martin, Michael;Vanichseni, Suphak
通讯作者：
Vanichseni, Suphak
影响因子：
4.9
作者：
Brooks, Ronald A.;Landovitz, Raphael J.;Barkley, Thomas W.
通讯作者：
Barkley, Thomas W.
影响因子：
7.2
作者：
Gale, Randall C.;Wu, Justina;Midboe, Amanda M.
通讯作者：
Midboe, Amanda M.