DEVELOPMENTAL VARIATIONS IN THE SPLICING PATTERN OF TRANSCRIPTS FROM THE DROSOPHILA GENE ENCODING MYOSIN ALKALI LIGHT CHAIN RESULT IN DIFFERENT CARBOXYL-TERMINAL AMINO-ACID SEQUENCES
DEVELOPMENTAL VARIATIONS IN THE SPLICING PATTERN OF TRANSCRIPTS FROM THE DROSOPHILA GENE ENCODING MYOSIN ALKALI LIGHT CHAIN RESULT IN DIFFERENT CARBOXYL-TERMINAL AMINO-ACID SEQUENCES
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DOI：
10.1073/pnas.82.2.449
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
DAVIDSON, N
中科院分区：
文献类型：
--
作者：
FALKENTHAL, S;PARKER, VP;DAVIDSON, N
The total sequence of the D. melanogaster gene encoding the myosin light chain dissociated by alkali (MLC-ALK) was determined. By sequence comparisons with an MLC-ALK [complement] cDNA clone and by S1 nuclease analyses, the pattern of introns and exons within the gene was deduced. There are multiple polyadenylylation signals that can account for most of the observed heterogeneity in the lengths of mRNAs. In the 3'' half of the gene, there are 2 alternative splicing patterns which result in mRNA that translate to give proteins with 2 alternative 14 amino acid carboxyl-terminal sequences. There is developmental regulation of the selection of the above splicing sites. One splicing pattern produces an mRNA that translates into a protein used for both larval and adult musculature, whereas the other splicing pattern is used for the latter stage only.
