Genotype determines phenotype in experimental Lyme borreliosis.
Genotype determines phenotype in experimental Lyme borreliosis.
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基因型决定实验性莱姆疏螺旋体病的表型。
DOI：
10.1002/ana.20192
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发表时间：
2004
影响因子：
11.2
通讯作者：
Cadavid,Diego
中科院分区：
文献类型：
--
作者：
Pachner,AndrewR;Dail,Donna;Bai,Yunhong;Sondey,Marie;Pak,Lena;Narayan,Kavitha;Cadavid,Diego
广义伯氏疏螺旋体（Borrelia burgdorferi sensu lato）是莱姆病的病原体，是一组异质性螺旋体，由至少三种致病性物种组成。为了验证遗传异质性是临床差异的原因这一假设，我们研究了欧洲分离株诱导的实验性疾病是否不同于美国分离株诱导的实验性疾病。两个美洲分离物B.与3个欧洲分离物、2个B. garinii和B. afzelii。由不同物种引起的感染、免疫和炎症的模式是不同的。炎症细胞和抗体水平。garinii和B. afzelii感染动物低于inB.在前一组动物中，皮肤和神经系统中的螺旋体感染水平较高。这些数据表明B.伯氏葡萄球菌菌株更具感染性和炎症性，而B.加里尼安湾阿氏杆菌菌株可以在更大程度上在适应性免疫应答中存活，并且在皮肤和神经系统中以更大的数量持续存在。这些结果在很大程度上解释了美国和欧洲人类LNB之间的差异。Ann Neurol 2004
Borrelia burgdorferi sensu lato, the causative organism of Lyme borreliosis, is a heterogeneous group of spirochetes, consisting of at least three pathogenic species. To test the hypothesis that the genetic heterogeneity is the reason for the clinical differences, we investigated whether the experimental disease induced by European isolates is different from that induced by American isolates. Two American isolates of speciesB. burgdorferi sensu strictowere compared with three European isolates, two of speciesB. garinii, and one of speciesB. afzelii. The patterns of infection, immunity, and inflammation induced by the different species was distinctive. Inflammatory cells and levels of antibody inB. garinii– andB. afzelii–infected animals were lower than inB. burgdorferi s.s.–infected animals, whereas levels of spirochetal infection in the skin and nervous system were higher in the former group of animals. These data demonstrate thatB. burgdorferi s.s.strains are more infective and inflammatory, whereasB. gariniiandB. afzeliistrains can survive the adaptive immune response to a greater degree and persist at greater numbers in the skin and nervous system. The results explain to a large extent the disparities between LNB in humans in the United States and Europe. Ann Neurol 2004