Reference Values and Calculation of z-Scores of Echocardiographic Measurements of the Normal Pediatric Right Ventricle
Reference Values and Calculation of z-Scores of Echocardiographic Measurements of the Normal Pediatric Right Ventricle
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DOI：
10.1016/j.amjcard.2014.08.028
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发表时间：
2014-11-15
影响因子：
2.8
通讯作者：
Gamillscheg, Andreas
中科院分区：
文献类型：
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作者：
Koestenberger, Martin;Nagel, Bert;Gamillscheg, Andreas
近年来，右心室（RV）大小和功能的测定在成人和儿童，特别是先天性心脏病患者中得到了越来越多的关注。关于儿童正常RV大小参数的数据很少。本研究的目的是探讨健康儿童队列中右心室内部尺寸的生长相关变化，以及右心室参数在鉴别第二型房间隔缺损（ASD）儿童右心室增大中的预测价值。一项前瞻性研究在576名健康儿童（1天至18岁）和37名中度至重度asd儿童（1.4至17.7岁）中进行。确定年龄、体长、体重和体表面积对以下RV参数的影响：舒张末期基底直径、舒张末期中腔直径、舒张末期长度、收缩末期长度、舒张末期面积和收缩末期面积。对asd患儿年龄、体重、体长、体表面积分层正常值的预测值进行检验。右心室舒张末期基底直径、舒张末期腔中直径、舒张末期长度、收缩末期长度、舒张末期面积、收缩末期面积与年龄、体长、体表面积、体重呈正相关。在该人群中，RV z评分在检测asd患者方面显示出很高的特异性，灵敏度高达89%，尤其是在儿童中
Determination of right ventricular (RV) size and function has gained more interest in recent years in adults and children, especially in patients with congenital heart disease. Data on normal RV size parameters in children are scant. The aim of this study was to investigate growth-related changes in RV internal dimensions in a healthy pediatric cohort and the predictive value of RV parameters in identifying enlarged right ventricles in children with secundum-type atrial septal defects (ASD). A prospective study was conducted in a group of 576 healthy children (aged 1 day to 18 years) and 37 children (aged 1.4 to 17.7 years) with moderate-sized to large ASDs. The effects of age, body length, body weight, and body surface area were determined on the following RV parameters: end-diastolic basal diameter, end-diastolic midcavity diameter, end-diastolic length, end-systolic length, end-diastolic area, and end-systolic area. The predictive value of normal values stratified for age, body weight, body length, and body surface area was tested in children with ASDs. RV end-diastolic basal diameter, end-diastolic midcavity diameter, end-diastolic length, end-systolic length, end-diastolic area, and end-systolic area showed positive correlations with age, body length, body surface area, and body weight. In this population, RV z scores showed high specificity for detecting patients with ASDs, with sensitivity up to 89%, especially in children