Long-term antidepressant use: patient perspectives of benefits and adverse effects.
Long-term antidepressant use: patient perspectives of benefits and adverse effects.
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DOI：
10.2147/ppa.s110632
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发表时间：
2016
影响因子：
2.2
通讯作者：
Dehar T
中科院分区：
文献类型：
--
作者：
Cartwright C;Gibson K;Read J;Cowan O;Dehar T
长期抗抑郁治疗已经增加，有证据表明有不良反应;然而，对患者的经验和这种形式的治疗的看法知之甚少。这项研究使用混合方法来检查患者对长期抗抑郁治疗的看法和经验，包括益处和担忧。来自180名长期使用抗抑郁药（3-15年）的患者的数据来自新西兰患者抗抑郁药经历的匿名在线调查。参与者完成了关于抗抑郁药的有效性，抗抑郁药使用前和使用期间的抑郁水平，生活质量和感知不良反应的评级量表。两个开放式问题允许参与者评论个人经历。大多数人（89.4%）报告说，抗抑郁药改善了他们的抑郁症，尽管30%的人报告说，抗抑郁药有中度至重度抑郁症。常见的不良反应包括戒断反应（73.5%）、性问题（71.8%）和体重增加（65.3%）。不良情绪影响，如感觉情感麻木（64.5%）和成瘾（43%）也很常见。虽然大多数患者对抗抑郁治疗的益处感到满意，但许多人担心这些不良反应。一些代表团表示，需要更多关于长期风险的信息，并需要更多的信息和支持，以停止使用。
Long-term antidepressant treatment has increased and there is evidence of adverse effects; however, little is known about patients’ experiences and views of this form of treatment. This study used mixed methods to examine patients’ views and experiences of long-term antidepressant treatment, including benefits and concerns. Data from 180 patients, who were long-term users of antidepressants (3–15 years), were extracted from an anonymous online survey of patients’ experiences of antidepressants in New Zealand. Participants had completed rating scales about the effectiveness of antidepressants, levels of depression before and during antidepressant use, quality of life, and perceived adverse effects. Two open-ended questions allowed participants to comment on personal experiences. The majority (89.4%) reported that antidepressants had improved their depression although 30% reported moderate-to-severe depression on antidepressants. Common adverse effects included withdrawal effects (73.5%), sexual problems (71.8%), and weight gain (65.3%). Adverse emotional effects, such as feeling emotionally numb (64.5%) and addicted (43%), were also common. While the majority of patients were pleased with the benefits of antidepressant treatment, many were concerned about these adverse effects. Some expressed a need for more information about long-term risks and increased information and support to discontinue.