Ultrasound tightening of facial and neck skin: A rater-blinded prospective cohort study
Ultrasound tightening of facial and neck skin: A rater-blinded prospective cohort study
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DOI：
10.1016/j.jaad.2009.06.039
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发表时间：
2010-02-01
影响因子：
13.8
通讯作者：
West, Dennis P.
中科院分区：
文献类型：
--
作者：
Alam, Murad;White, Lucile E.;West, Dennis P.
背景资料：非消融性皮肤紧致技术提供了减少皱纹和皮肤下垂的前景，同时减少停机时间、不适和不良事件的风险。优秀的安全配置文件是减轻了有限的疗效，这样的programmes.Objective：我们寻求评估的疗效，超声皮肤收紧眉升降机的程序治疗的背景下，全脸和neck.Methods：这是一个评分盲，前瞻性队列研究，在皮肤科诊所在城市学术医疗中心。受试者接受局部麻醉剂治疗，然后使用以下探头在前额、太阳穴、脸颊、颏下区和颈部侧面使用研究用聚焦强超声收紧装置进行治疗：4 MHz，4.5 mm焦深; 7 MHz：4.5 mm焦深; 7 MHz，3.0 mm焦深。在2、7时获得标准化的正面和侧面照片。28、60和90天;还完成了疼痛、不良事件、体格检查结果和患者满意度的评定量表。主要结局指标是由3名不知情的专家医师评估员、美容和激光皮肤科医生以及非作者的整形外科医生对治疗前和治疗后（第90天）照片进行配对比较，检测改善情况。第二个主要结果测量是客观的眉毛抬高，通过使用固定标志的标准程序进行定量。第二个结果测量是病人的满意度作为衡量的questionnaire.Results：共36名受试者（34名女性）入组，1名受试者脱落，和35名受试者进行了评价。中位年龄为44岁（范围32-62岁）。在第一个主要结局指标上，35例受试者中有30例（86%）被3名经验丰富的盲态临床医师评定者判定为治疗后90天出现临床显著的提眉（P=.00001）。在第二个主要结果的措施，平均值在眉毛高度的平均变化，在90天的照片测量评估为1.7毫米。局限性：局限性thiS研究包括无法定量测量下面部紧缩，因为缺乏固定的解剖标志，在这一领域。结论：超声似乎是一个安全有效的方式面部皮肤紧缩。一个单一的超声波治疗的前额产生油平均眉高海拔略低于2毫米。通常伴有短暂的轻度红斑和水肿。（J Am Acad Dermatol 2010;62：262-9.）
Background: Nonablative skin tightening technologies offer the Prospect Of reduction of wrinkles and skin sagging with minimal downtime, discomfort, and risk of adverse events. The excellent safety profile is mitigated by the limited efficacy of such procedures.Objective: We Sought to assess the efficacy of ultrasound skin tightening for brow-lift in the context of a procedure treating the full face and neck.Methods: This was a rater-blinded, prospective cohort study at a dermatology clinic in an urban academic medical center. Subjects were medicated with topical anesthetic and then treated with an investigational focused intense Ultrasound tightening device to the forehead, temples, cheeks, submental region, and side of neck using the following probes: 4 MHz, 4.5-mm focal depth; 7 MHz: 4.5-mm focal depth; and 7 MHz, 3.0-mm focal depth. Standardized photographs of front and side views were obtained at 2, 7. 28, 60, and 90 days; rating scales of pain, adverse events, physical findings, and patient satisfaction were also completed. Primary outcome Measure was detection of improvement in paired comparison of pretreatment and posttreatment (day 90) photographs by 3 masked expert physician assessors, cosmetic and laser dermatologists, and plastic Surgeons who were not authors. Second primary outcome measure was objective brow elevation as quantitated by a standard procedure using fixed landmarks. Secondary outcomes measure was patient satisfaction as measured by a questionnaire.Results: A total of 36 subjects (34 female) were enrolled, One Subject dropped out, and 35 subjects were evaluated. Median age was 44 years (range 32-62). On the first primary outcome measure, 30 of 35 subjects (86%) were judged by the 3 masked experienced clinician raters to Show clinically significant brow-lift 90 days after treatment (P=.00001). On the second primary outcome measure, mean value of average change in eyebrow height as assessed by measurements Of Photographs at 90 days was 1.7 mm.Limitations: Limitations Of thiS study include the inability to quantitatively measure lower face tightening because Of the lack of fixed anatomic landmarks in this area.Conclusion: Ultrasound appears to be a safe and effective modality for facial skin tightening. A single Ultrasound treatment of the forehead produced Oil average brow height elevation of slightly less than 2 mm. Most treated individuals responded. commonly with accompanying transitory mild erythema and edema. (J Am Acad Dermatol 2010;62:262-9.)