The Great Recession and health risks in African American youth.
The Great Recession and health risks in African American youth.
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DOI：
10.1016/j.bbi.2015.12.015
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Brody GH
中科院分区：
文献类型：
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作者：
Chen E;Miller GE;Yu T;Brody GH
在本研究中，我们调查了宏观经济条件-大衰退-与细胞表观遗传衰老，非稳态负荷和自我报告的健康的关联，在一组经历显着的健康差异，非裔美国人。从经济衰退前（2007年，M年龄=16.6）到经济衰退后（2010年，M年龄=19.3），对格鲁吉亚的330名非洲裔美国青少年进行了跟踪调查。2007年和2010年收集了经济数据。三组被形成来代表整个大衰退时期的经济轨迹（稳定的低经济困难，向下流动和稳定的高经济困难）。在19岁时，获得了细胞表观遗传衰老（来自白细胞DNA甲基化谱，反映了一个人的生物学和实际年龄之间的差异），非稳态负荷（血压，C反应蛋白，皮质醇，肾上腺素，去甲肾上腺素和体重指数的复合物）和青少年自我报告的健康状况。线性趋势分析记录了所有结局的显著差异。青少年在经济困难下度过的时间越长，他们的表观遗传衰老[估计值=1.421，se=0.466，p=.002]和非稳态负荷[估计值=1.151，se=0.375，p=.002]得分越高，他们的自我健康报告越差[估计值=4.957，se=1.800，p=.006]。具体的组比较显示，向下流动组的青少年比稳定低困难组的青少年有更高水平的非稳态负荷[p<0.05]。总体而言，这些研究结果表明，非洲裔美国青年的健康状况可能部分是由环境宏观经济社会条件形成的，并且可以在生命的早期检测到对生物标志物的影响。
In the present study, we investigated associations of macro-economic conditions - the Great Recession - with cellular epigenetic aging, allostatic load, and self-reported health, in a group that experiences significant health disparities, African Americans. A sample of 330 African American adolescents in Georgia was followed from pre-recession (2007, M age=16.6) to post-recession (2010, M age=19.3). Economic data were collected in both 2007 and 2010. Three groups were formed to represent economic trajectories across the period of the Great Recession (stable low economic hardship, downward mobility, and stable high economic hardship). At age 19, measures of cellular epigenetic aging (derived from leukocyte DNA methylation profiles, reflecting the disparity between a person’s biological and chronological age), allostatic load (composite of blood pressure, C reactive protein, cortisol, epinephrine, norepinephrine, and body mass index), and adolescent self-report of health were obtained. Linear trend analyses documented significant differences across all outcomes. The more time adolescents spent under economic hardship, the higher their epigenetic aging [estimate=1.421, se=0.466, p=.002] and allostatic load [estimate=1.151, se=0.375, p=.002] scores, and the worse their self-report of health [estimate=4.957, se=1.800, p=.006]. Specific group comparisons revealed that adolescents in the downward mobility group had higher levels of allostatic load than adolescents in the stable low hardship group [p<.05]. Overall, these findings suggest that the health profiles of African American youth may in part be shaped by environmental macro-economic societal conditions, and that effects on biological markers can be detected relatively early in life.