Minimally Required Iodine Dose for the Detection of Hypervascular Hepatocellular Carcinoma on 80-kVp CT
Minimally Required Iodine Dose for the Detection of Hypervascular Hepatocellular Carcinoma on 80-kVp CT
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DOI：
10.2214/ajr.15.15138
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发表时间：
2016-03-01
影响因子：
5
通讯作者：
Bae, Kyongtae T.
中科院分区：
文献类型：
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作者：
Goshima, Satoshi;Kanematsu, Masayuki;Bae, Kyongtae T.
目标。本研究的目的是确定在80-KVP CT上检测高血管肝细胞癌所需的单位体重(BW)或体表面积(BSA)的最低碘剂量。111例慢性肝炎患者(男78例，女33例；平均年龄68岁；年龄43~85岁)随机分为3组，每组30例，碘负荷分别为0.5、0.4和0.3g I/kg BW，扫描速度为80kVp。在肝动脉、门静脉和平衡期图像上定量和定性地评估肝脏和多血供肝细胞癌的增强情况，并比较两组之间的差异。计算并分析每单位牛血清白蛋白的碘剂量(gi/m(2))。结果：两组间各时相高血管肝癌的对比噪声比(CNR)无显著差异(p=0.34-0.99)。在门静脉期，0.5gI/kg组(80.3HU)的平均增强幅度(Delta HU)高于0.4gI/kg组(63.4HU)和0.3gI/kg组(53.3HU)(p<；0.001)。肝脏增强增强的线性相关方程为：Delta Hu=5.9+150.0 x ILBW(r=0.69，p<；0.001)，其中ILBW为单位体重碘负荷(gI/kg)，Delta Hu=13.0+3.68x ILBSA(r=0.66，p<；0.001)，其中ILBSA是BSA的碘负荷前单位(gI/m(2))。结论：在80kVP CT上获得可接受的肿瘤与肝脏的CNR所需的最低碘剂量为0.3g I/kgBW或11.0gI/m(2)BSA。
OBJECTIVE. The objective of our study was to determine the iodine dose per unit of body weight (BW) or body surface area (BSA) that is minimally required to detect hypervascular hepatocellular carcinoma (HCC) on 80-kVp CT.SUBJECTS AND METHODS. One hundred eleven patients (78 men and 33 women; mean age, 68 years; age range, 43-85 years) with chronic hepatitis were randomized into three groups with different iodine loads (0.5, 0.4, and 0.3 g I/kg BW) and underwent contrast-enhanced CT at 80 kVp. Enhancement of the liver and of hypervascular HCCs was quantitatively and qualitatively assessed on hepatic arterial, portal venous, and equilibrium phase images and compared between the groups. Values for iodine dose per unit of BSA (g I/m(2)) were also computed and analyzed.RESULTS. No significant differences in the contrast-to-noise ratio (CNR) of hypervascular HCCs in any phase were found between the groups (p = 0.34-0.99). In the portal venous phase, the mean increase in hepatic contrast enhancement (Delta HU) of the 0.5 g I/kg group (80.3 HU) was higher than those of the 0.4 g I/kg (63.4 HU) and 0.3 g I/kg (53.3 HU) groups (p < 0.001). Linear correlation equations for the increase in hepatic contrast enhancement were as follows: Delta HU = 5.9 + 150.0 x ILBW (r = 0.69, p < 0.001), where ILBW is the iodine load per unit of BW (g I/kg), and Delta HU = 13.0 + 3.68 x ILBSA (r = 0.66, p < 0.001), where ILBSA is the iodine load pre unit of BSA (g I/m(2)).CONCLUSION. The minimal iodine dose required to achieve a tumor-to-liver CNR that is acceptable for the detection of hypervascular HCCs on 80-kVp CT was 0.3 g I/kg BW or 11.0 g I/m(2) BSA.