7 mg nicotine patch fails to enhance P300 neural indices of cognitive control among nonsmokers
7 mg nicotine patch fails to enhance P300 neural indices of cognitive control among nonsmokers
复制标题
DOI：
10.1016/j.pbb.2014.09.001
复制
发表时间：
2014-11-01
影响因子：
3.6
通讯作者：
Drobes, David J.
中科院分区：
文献类型：
--
作者：
Evans, David E.;Jentink, Kade G.;Drobes, David J.
尼古丁管理促进和尼古丁剥夺减少吸烟者的认知控制。重要的是，尼古丁对认知的影响可能会加强吸烟行为，特别是在有认知缺陷的人中。目标P300（P3 b）和分心P300（P3 a）是有效的注意和记忆相关的认知控制过程的皮层电标记。尼古丁剥夺已被证明会降低P3 b/P3 a振幅。目前的研究试图检查尼古丁对非吸烟者P3 b/P3 a振幅的直接影响。据推测，尼古丁会增加P3 b和P3 a的振幅，和个人较低的特质认知控制将显示更大的尼古丁诱导的增加。78名非吸烟者参加了两个独立的实验，在此期间，他们在尼古丁（7 mg）或安慰剂贴剂给药后进行P3 b/P3 a诱发3刺激古怪任务。尼古丁没有增强P3 b或P3 a振幅，也没有特质认知控制中度尼古丁对这些指标的影响。尼古丁诱导的P3振幅变化可能仅限于尼古丁剥夺和/或非吸烟者可能在尼古丁对认知控制的P3 b/P3 a指数的影响方面存在根本性差异。未来的研究方向，可能会进一步研究尼古丁对P3 b/P3 a独立的撤回逆转的影响进行了讨论。(C)版权所有© 2014 Elsevier Inc.
Nicotine administration facilitates and nicotine deprivation reduces cognitive control in smokers. Importantly, nicotine effects on cognition may reinforce smoking behavior, especially among individuals who have cognitive deficits. The target P300 (P3b) and distracter P300 (P3a) are well-validated electrocortical markers of attention- and memory-related cognitive control processes. Nicotine deprivation has been shown to reduce P3b/P3a amplitudes. The current study sought to examine the direct effects of nicotine on P3b/P3a amplitudes among nonsmokers. It was hypothesized that nicotine would increase P3b and P3a amplitudes, and that individuals lower on trait cognitive control would show greater nicotine-induced increases. 78 nonsmokers attended two separate experimental sessions, during which they performed the P3b/P3a evoking 3-stimulus oddball task following nicotine (7-mg) or placebo patch administration. Nicotine did not enhance P3b or P3a amplitudes, nor did trait cognitive control moderate the influence of nicotine on these indices. Nicotine-induced changes in P3 amplitudes may be limited to nicotine deprivation and/or nonsmokers may be fundamentally different with respect to the influence of nicotine on P3b/P3a indices of cognitive control. Directions for future research that may further examine the effects of nicotine on P3b/P3a independent of withdrawal reversal are discussed. (C) 2014 Elsevier Inc All rights reserved.