An Improved Method for Acquiring Cerebrovascular Reactivity Maps
An Improved Method for Acquiring Cerebrovascular Reactivity Maps
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DOI：
10.1002/mrm.22719
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发表时间：
2011-05-01
影响因子：
3.3
通讯作者：
Gowland, Penny A.
中科院分区：
文献类型：
--
作者：
Blockley, Nicholas P.;Driver, Ian D.;Gowland, Penny A.
本研究旨在改进MRI脑血管反应性（CVR）图的制作方法。先前的方法使用二氧化碳（CO2）的标准矩形表示。在这里，这被替换为正弦调制的CO2刺激。这允许使用傅立叶分析技术来测量BOLD CVR响应的幅度和相位延迟，从而表征血液到达大脑不同区域的顺序。该表征揭示了大脑区域之间的统计学显著的相对延迟（ANOVA < 0.0001）。此外，事后比较显示额叶（P < 0.001）和顶叶（P = 0.004）比枕叶反应更早。Magn Reson Med 65：1278-1286，2011. (c)2010 Wiley-Liss，Inc.
This study aims to improve the method used to produce cerebrovascular reactivity (CVR) maps by MRI. Previous methods have used a standard boxcar presentation of carbon dioxide (CO2). Here this is replaced with a sinusoidally modulated CO2 stimulus. This allowed the use of Fourier analysis techniques to measure both the amplitude and phase delay of the BOLD CVR response, and hence characterize the arrival sequence of blood to different regions of the brain. This characterization revealed statistically significant relative delays between regions of the brain (ANOVA < 0.0001). In addition, post hoc comparison showed that the frontal (P < 0.001) and parietal (P = 0.004) lobes reacted earlier than the occipital lobe. Magn Reson Med 65:1278-1286, 2011. (c) 2010 Wiley-Liss, Inc.