Positron Annihilation Lifetime Spectroscopy (PALS) as a Characterization Technique for Nanostructured Self-Assembled Amphiphile Systems
Positron Annihilation Lifetime Spectroscopy (PALS) as a Characterization Technique for Nanostructured Self-Assembled Amphiphile Systems
复制标题
DOI：
10.1021/jp805280r
复制
发表时间：
2009-01-08
影响因子：
3.3
通讯作者：
Drummond, Calum J.
中科院分区：
文献类型：
--
作者：
Dong, Aurelia W.;Pascual-Izarra, Carlos;Drummond, Calum J.
正电子湮没寿命谱（帕尔斯）是一种快速表征两亲分子自组装体系的新方法，但由于缺乏帕尔斯参数与结构属性之间的系统关联性，限制了其更广泛的应用。在这项研究中，使用良好的特点植烷三醇/水和植烷三醇/维生素E醋酸酯/水自组装两亲体系，系统的结构变化控制的组成和温度的变化对帕尔斯参数的影响进行了研究。的帕尔斯参数（orthopositronium（oPs）的寿命和强度签名）被证明是敏感的分子包装和流动性的自组装脂质分子在各种溶致液晶相，使液晶结构之间的差异。与分子堆积和流动性相关的oPs寿命与各个中间相的流变学性质相关。oPs寿命将各种中间相中的脂质链包装和流动性与所得宏观性质（例如渗透性）联系起来，这对于将这些中间相结构用作活性脂溶性化合物的扩散控制释放基质是关键的。
Positron annihilation lifetime spectroscopy (PALS) has potential as a novel rapid characterization method for self-assembly amphiphile systems; however, a lack of systematic correlation of PALS parameters with structural attributes has limited its more widespread application. In this study, using the well-characterized phytantriol/water and the phytantriol/vitamin E acetate/water self-assembly amphiphile systems, the impact of systematic structural changes controlled by changes in composition and temperature on PALS parameters has been studied. The PALS parameters (orthopositronium (oPs) lifetime and intensity signatures) were shown to be sensitive to the molecular packing and mobility of the self-assembled lipid molecules in various lyotropic liquid crystalline phases, enabling differentiation between liquid crystalline structures. The oPs lifetime, related to the molecular packing and mobility, is correlated with theological properties of the individual mesophases. The oPs lifetime links the lipid chain packing and mobility in the various mesophases to resultant macroscopic properties, such as permeability, which is critical for the use of these mesophase structures as diffusion-controlled release matrices for active liposoluble compounds.