High expression of ENPP2 is an independent predictor of poor prognosis in liver cancer.
High expression of ENPP2 is an independent predictor of poor prognosis in liver cancer.
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DOI：
10.1097/md.0000000000034480
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发表时间：
2023-08-04
期刊：
影响因子：
1.6
通讯作者：
中科院分区：
文献类型：
--
作者：
胞外核苷酸焦磷酸/磷酸二酯酶2(ENPP2)已被认为是肺癌和前列腺癌的潜在生物标志物，但其在肝细胞癌中的表达及其临床意义仍不完全清楚。这项研究利用生物信息学综合评估了ENPP2在泛癌中的表达。我们利用TCGA数据库中的数据分析了ENPP2在原发性肝癌及癌旁组织中的表达。采用COX回归和Kaplan-Meier方法分析影响生存率的临床病理因素，并通过受试者工作特征曲线分析评价ENPP2表达对乳腺癌的诊断价值。我们还通过对临床肝癌样本进行实时聚合酶链式反应来验证我们的发现。此外，我们使用癌症基因组图谱数据集进行了基因集浓缩分析，以进一步了解ENPP2在肝细胞癌中的生物学意义。ENPP2在肝癌患者中的高表达与性别和临床分期有关，是预后不良的重要预后因素。在这两个队列中，ENPP2的表达是无进展和疾病特异性生存的独立危险因素，表明其作为肝癌生物标记物的潜力。受试者工作特征曲线下面积为0.806，证实了ENPP2‘S对肝癌患者的诊断价值。实时荧光定量聚合酶链式反应分析证实了ENPP2在临床肝癌组织中的高表达。基因集浓缩分析确定了在高表达ENPP2的肝癌患者中丰富的途径，包括与细胞周期、MTOR和T细胞受体信号以及磷脂酰肌醇信号系统相关的途径。我们已经证明，ENPP2在肝细胞癌中高表达，是一种潜在的独立分子标志物，可用于肝细胞癌的诊断和预后判断。
Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) has been identified as a potential biomarker in lung and prostate cancers; however, its expression and clinical relevance in hepatocellular carcinoma (HCC) remain incompletely understood. This study comprehensively assessed ENPP2 expression in pan-cancer using bioinformatics. We analyzed the expression of ENPP2 mRNA in primary liver cancer and adjacent tissues of patients with HCC using data from the TCGA database. Cox regression and Kaplan–Meier methods were used to identify clinicopathological factors associated with survival, and the diagnostic value of ENPP2 expression was evaluated using receiver operating characteristic curve analysis. We also validated our findings by performing real-time PCR on clinical liver cancer samples. Furthermore, we conducted gene set enrichment analysis using the Cancer Genome Atlas dataset to gain additional insights into the biological significance of ENPP2 in HCC. High ENPP2 expression in HCC patients is associated with gender and clinical stage, and is a significant prognostic factor for worse outcomes. ENPP2 expression is an independent risk factor for progression-free and disease-specific survival in both cohorts, suggesting its potential as an HCC biomarker. ENPP2’s diagnostic value in HCC patients was confirmed by the area under the receiver operating characteristic curve, which was 0.806. real-time PCR analysis validated the higher expression of ENPP2 in clinical liver cancer tissues. Gene set enrichment analysis identified pathways enriched in HCC patients with high ENPP2 expression, including those related to the cell cycle, MTOR and T cell receptor signaling, and phosphatidylinositol signaling systems. We have demonstrated that ENPP2 is highly expressed in HCC and is a potential independent molecular marker for the diagnosis and prognosis of HCC.
乙型肝炎病毒通过促进ENPP2的表达和分泌与肝星状细胞协同促进肝细胞癌进展
影响因子：
5
作者：
Deng W;Chen F;Zhou Z;Huang Y;Lin J;Zhang F;Xiao G;Liu C;Liu C;Xu L
通讯作者：
Xu L