SPECIFICITY AND FUNCTION OF T-CELLS BEARING GAMMA-DELTA-RECEPTORS
SPECIFICITY AND FUNCTION OF T-CELLS BEARING GAMMA-DELTA-RECEPTORS
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DOI：
10.1016/0167-5699(88)91267-4
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发表时间：
1988-03-01
期刊：
影响因子：
--
通讯作者：
HAYDAY, A
中科院分区：
文献类型：
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作者：
JANEWAY, CA;JONES, B;HAYDAY, A
现在清楚的是，基于所表达的异二聚体受体链（0 ~或~ 1~）的性质，可以定义携带CD 3抗原的两种T细胞谱系。在这里，Charles Janeway及其同事推测，~ 1受体（TCR 1）可能在很大程度上对I类MHC（主要组织相容性复合体）抗原具有特异性，与大多数体细胞上表达的抗原不同。携带TCR 1的细胞具有两种潜在的功能，即监视上皮细胞和分化携带TCR 2的T细胞，负责识别抗原的T细胞受体在自身MHC编码分子的背景下的逃逸性已经引起细胞和分子免疫学家的注意。现在已经确定，编码这些结构的α-和β-链的基因可以解释表达它们的细胞的特异性，尽管抗原-MHC识别的分子细节还不清楚。此外，携带这些受体的细胞的许多功能已经被很好地表征。然而，对难以捉摸的T细胞受体的追求揭示了一个同样感兴趣且功能未知的基因，T细胞受体样基因3。在这里，迫切需要一个连贯的范式来解释这个基因的结构及其在免疫反应中的功能。在这篇文章中，我们提出了一个假设来解释~/基因的结构和表达，并提出了表达该基因的细胞的功能。
It is now clear that two lineages of T cells bearing the CD3 antigen can be defined, based on the nature of the heterodimeric receptor chains (o~ or~ 1~) expressed. Here, Charles Janeway and colleagues speculate that the~ 1~ receptors (TCR1) may be largely specific for class I MHC (major histocompatibility complex) antigens different from those expressed on most somatic cells. Two potential functions of TCR l-bearing cells are surveillance of epithelia and differentiation of T cells bearing~ receptors (TCR2) in the thymus.The elusiveness of the T-cell receptor responsible for the recognition of antigen in the context of self MHC-encoded molecules has yielded to cellular and molecular immunologists. It is now well established that the genes encoding the o~ and 13 chains of these structures can account for the specificity of the cells expressing them 1.2, although the molecular details of antigen-MHC recognition are not yet understood. Furthermore, many functions of cells bearing these receptors have been well characterized. However, the pursuit of the elusive T-cell receptor revealed a gene of equal interest and unknown function, the T-cell receptor-like~, gene 3. Here, the great need is for a coherent paradigm to explain the structure of this gene and its function in the immune response. In this article, we propose an hypothesis to account for~/gene structure and expression, and suggest a function for the cells that express this gene.