Kynurenic acid prevented social recognition deficits induced by MK-801 in rats
Kynurenic acid prevented social recognition deficits induced by MK-801 in rats
复制标题
DOI：
10.33549/physiolres.930427
复制
发表时间：
2003-01-01
影响因子：
2.1
通讯作者：
Krejcí, I
中科院分区：
文献类型：
--
作者：
Hlinák, Z;Krejcí, I
MK-801在与幼年大鼠初次互动后立即给予，会损害成年雄性大鼠的社会识别能力。在初始相互作用之前给予犬尿酸可以保护成人免受MK-801诱导的识别缺陷。当延迟30分钟再次暴露于熟悉的青少年时，成人的社会调查显著减少。因此，成虫能够记住幼鱼发出的嗅觉刺激。
MK-801 impaired social recognition potency of adult male rats when given immediately after the initial interaction with a juvenile rat. Administration of kynurenic acid prior to the initial interaction protected the adults against recognition deficits induced by MK-801. When re-exposed at a delay of 30 min to the familiar juvenile, social investigation in the adults was significantly reduced. Thus, the adults are able to remember olfactory stimuli emitted by juvenile conspecifies.