Distribution of 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl free radical in normal and neoplastic animal tissues.
Distribution of 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl free radical in normal and neoplastic animal tissues.
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2,2,6,6-四甲基-4-氧代哌啶-1-氧基自由基在正常和肿瘤动物组织中的分布。
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
N. Yordanov
中科院分区：
文献类型：
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作者：
P. Blagoeva;Z. Raikov;I. Chernozemsky;I. Nikolov;N. Yordanov
将自由基2，2，6，6-四甲基-4-氧代哌啶-1-氧基（TMPO）以100毫克/千克体重的剂量腹腔注射到叙利亚仓鼠（未经治疗、部分肝切除并移植有可移植肿瘤）以及患有B16黑色素瘤或腺癌的小鼠中。在应用该化合物一小时后，通过光谱法测定其在肝、肾、肺和所有肿瘤中的含量。在仓鼠和小鼠黑色素性黑素瘤中记录了TMPO的特征性三联信号，但在所有其他动物组织和肿瘤中未记录。这可能是黑色素性黑素瘤细胞中的酶缺陷或黑色素对TMPO的保留的结果。还发现TMPO主要在动物的肝脏中代谢。
The free radical 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl (TMPO) was injected i.p. in doses of 100 mg/kg bw into Syrian hamsters: untreated, partially hepatectomized and grafted with transplantable tumours as well as into mice with B16 melanotic melanoma or with an adenocarcinoma. One hour after application of the compound its content was determined spectrometrically in livers, kidneys, lungs and all tumours. The characteristic triplet signal of TMPO was registered in the hamster and mouse melanotic melanomas but not in all other animal tissues and tumours. This may be the result of an enzyme defect in the melanotic melanoma cells or of a retention of TMPO by melanin. It was also found that TMPO is metabolized predominantly in the livers of the animals.