A multicentre mortality study of workers exposed to ethylene oxide.
A multicentre mortality study of workers exposed to ethylene oxide.
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对接触环氧乙烷的工人进行的多中心死亡率研究。
DOI：
10.1136/oem.47.3.182
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Stocker
中科院分区：
文献类型：
--
作者：
N. Kiesselbach;K. Ulm;H;U. Korallus;Arztliche Abteilung;AG Bayer;D;Dietrich Plant No 40 Bayer;Leverkusen Ag;Frankfurt Hoechst AG;M. J. Stasik;Plant No;Gendorf H Hoglmeier;Ag Basf;G. LudwigshafenW;Stocker
进行了一项多中心队列研究，以研究环氧乙烷暴露与癌症死亡率之间的可能关联。该队列由来自联邦共和国德国6家化学公司的8家化工厂的2658名男性组成，他们在1928年至1981年期间暴露于环氧乙烷至少一年。独立工厂的受试者人数从98人到604人不等。到研究结束之日（1982年12月31日），268人死亡，68人死于恶性肿瘤。对于63名离开工厂的员工（2.4%），生命状态仍然未知。与全国死亡率相比，所有死亡原因的标准化死亡率为0.87，所有恶性肿瘤为0.97。当使用当地州费率时，最低限度标准费率略低。观察到2例白血病死亡，而预期为2.35例（SMR = 0.85）。食管癌（2.0）和胃癌（1.38）的SMR有所提高，但无显著性。在一个工厂中，选择了一个年龄、性别和入厂日期相匹配的内部“对照组”，并与接触组进行比较。在这两组中，观察到了“健康工人效应”。接触组的总死亡率和恶性肿瘤死亡率高于对照组;差异无统计学意义。接触组中没有人死于白血病，对照组中有1人死于白血病。
A multicentre cohort study was carried out to study the possible association between exposure to ethylene oxide and cancer mortality. The cohort consisted of 2658 men from eight chemical plants of six chemical companies in the Federal Republic of Germany who had been exposed to ethylene oxide for at least one year between 1928 and 1981. The number of subjects in the separate plants varied from 98 to 604. By the closing date of the study (31 December 1982) 268 had died, 68 from malignant neoplasms. For 63 employees who had left the plant (2.4%) the vital status remained unknown. The standardised mortality ratio for all causes of death was 0.87 and for all malignancies 0.97 compared with national rates. When local state rates were used the SMRs were slightly lower. Two deaths from leukaemia were observed compared with 2.35 expected (SMR = 0.85). SMRs for carcinoma of the oesophagus (2.0) and carcinoma of the stomach (1.38) were raised but not significantly. In one plant an internal "control group" was selected matched for age, sex, and date of entry into the factory and compared with the exposed group. In both groups a "healthy worker effect" was observed. The total mortality and mortality from malignant neoplasms was higher in the exposed than in the control group; the differences were not statistically significant. There were no deaths from leukaemia in the exposed group and one in the control group.